SynthesisThe Journal of nutrition2021
Protein Source and Quality for Skeletal Muscle Anabolism in Young and Older Adults: A Systematic Review and Meta-Analysis.
Synthesis in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07253714 (THE EFFECT OF PROPRIOCEPTIVE EXERCISE TRAINING ON CERVICAL PROPRIOCEPTION, KINESIOPHOBIA, AND PAIN CATASTROPHIZING LEVELS IN SARCOPENIC GERIATRIC INDIVIDUALS RESIDING IN NURSING HOMES), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Pooled it
- Reducing meat and/or dairy consumption in adults: a systematic review and meta-analysis of effects on protein intake, anthropometric values, and body composition.Nutrition reviews · 2024Pooled it
- Effect of a protein intervention during resistance training with varying training intensities on muscle outcomes in frail community-dwelling older adults: a randomized controlled trial.The journal of nutrition, health & aging · 2026Trial
- Trial
- Investigating the Digestibility, Bioavailability and Utilization of Protein Blends in Older Adults Using a Dual Stable Isotope Tracer Technique.Nutrients · 2025Trial
- Postprandial plasma amino acid and appetite responses to a low protein breakfast supplemented with whey or pea protein in middle-to-older aged adults.European journal of nutrition · 2025Trial
- Postprandial plasma aminoacidemia and indices of appetite regulation following pea-rice blend, pea isolate and whey protein ingestion in healthy young adults.The British journal of nutrition · 2024Trial
- High-Moisture Extrusion of a Dietary Protein Blend Impairs In Vitro Digestion and Delays In Vivo Postprandial Plasma Amino Acid Availability in Humans.The Journal of nutrition · 2024Trial
- Trial
- Review
- Nutrition's role in extending healthspan: CRN-international symposium report.European journal of nutrition · 2026Article
- From molecular mechanisms to nutritional applications: protein and polyphenol interventions in sarcopenia.Journal of physiology and biochemistry · 2026Review
- Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.Translational sports medicine · 2026Review
- Food matrix in the context of muscle and whole-body protein synthesis: a scoping review.Nutrition & metabolism · 2025Review
- Protective Effects of Mackerel Protein Hydrolysates Against Oxidative Stress-Induced Atrophy in C2C12 Myotubes.Foods (Basel, Switzerland) · 2025Article
- Dietary protein intake and overall diet quality in adults with cystic fibrosis following elexacaftor/tezacaftor/ivacaftor therapy.The British journal of nutrition · 2025Observational
- Design and Implementation of the Protein-Distinct Macronutrient-Equivalent Diet (PRODMED) Study: An Eighteen-Week Randomized Crossover Feeding Trial Among Free-Living Rural Older Adults.Current developments in nutrition · 2025Article
- Relationship between dietary protein and amino acid intake and handgrip strength in Korean adults: data from the 2014-2019 Korea National Health and Nutrition Examination Survey.Nutrition journal · 2025Article
- Dietary protein considerations in a sustainable and ageing world: a narrative review with a focus on greenhouse gas emissions and skeletal muscle remodelling and maintenance.BMC musculoskeletal disorders · 2024Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is much debate regarding the source/quality of dietary proteins in supporting indices of skeletal muscle anabolism.
objectiveWe performed a systematic review and meta-analysis to determine the effect of protein source/quality on acute muscle protein synthesis (MPS) and changes in lean body mass (LBM) and strength, when combined with resistance exercise (RE).
methodsA systematic search of the literature was conducted to identify studies that compared the effects of ≥2 dose-matched, predominantly isolated protein sources of varying "quality." Three separate models were employed as follows: 1) protein feeding alone on MPS, 2) protein feeding combined with a bout of RE on MPS, and 3) protein feeding combined with longer-term resistance exercise training (RET) on LBM and strength. Further subgroup analyses were performed to compare the effects of protein source/quality between young and older adults. A total of 27 studies in young (18-35 y) and older (≥60 y) adults were included.
resultsAnalysis revealed an effect favoring higher-quality protein for postprandial MPS at rest [mean difference (MD): 0.014%/h; 95% CI: 0.006, 0.021; P < 0.001] and following RE (MD: 0.022%/h; 95% CI: 0.014, 0.030; P < 0.00001) in young (model 1: 0.016%/h; 95% CI: -0.004, 0.036; P = 0.12; model 2: 0.030%/h; 95% CI: 0.015, 0.045; P < 0.0001) and older (model 1: 0.012%/h; 95% CI: 0.006, 0.018; P < 0.001; model 2: 0.014%/h; 95% CI: 0.007, 0.021; P < 0.001) adults. However, although higher protein quality was associated with superior strength gains with RET [standardized mean difference (SMD): 0.24 kg; 95% CI: 0.02, 0.45; P = 0.03)], no effect was observed on changes to LBM (SMD: 0.05 kg; 95% CI: -0.16, 0.25; P = 0.65).
conclusionsThe current review suggests that protein quality may provide a small but significant impact on indices of muscle protein anabolism in young and older adults. However, further research is warranted to elucidate the importance of protein source/quality on musculoskeletal aging, particularly in situations of low protein intake.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.