ArticleArteriosclerosis, thrombosis, and vascular biology2021
Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanotransduction in Marfan Syndrome and Related Aortic Disorders: Insights from Transcriptomic Analyses.Genes · 2026Review
- Preclinical modeling of Loeys-Dietz syndrome: insights into mechanisms and therapy.Orphanet journal of rare diseases · 2026Review
- Long-term loss of TGF-β signaling in smooth muscle cells of aged adult mice disrupts proximal aortic wall structure and homeostasis.Scientific reports · 2026Article
- Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF-β Pathway Inhibition.Journal of the American Heart Association · 2025Article
- Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection.JCI insight · 2025Article
- Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.The journal of cardiovascular aging · 2025Article
- Fibrillin-1 Deficiency Perturbs Aortic Cholinergic Relaxation and Adrenergic Contraction in a Mouse Model of Early Onset Progressively Severe Marfan Syndrome.Journal of vascular research · 2025Article
- Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells.Frontiers in cardiovascular medicine · 2024Review
- FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.Nature communications · 2023Article
- Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease.International journal of molecular sciences · 2023Review
- The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection.European heart journal · 2023Article
- Distinct Mechanisms of β-Arrestin-Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Molecular Mechanisms in Genetic Aortopathy-Signaling Pathways and Potential Interventions.International journal of molecular sciences · 2023Review
- Endothelial dysfunction in Marfan syndrome mice is restored by resveratrol.Scientific reports · 2022Article
- Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft.Advanced healthcare materials · 2022Review
- Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion ofArteriosclerosis, thrombosis, and vascular biology · 2022Article
- Review
- Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders.Cardiovascular pathology : the official journal of the Society for Cardiovascular PathologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Jay ZhuSurgery (J.Z.), University of Washington, Seattle.
Stoyan AngelovDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
Ilkay Alp YildirimDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
Hao WeiDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
Jie Hong HuDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
Mark W MajeskyPediatrics (M.W.M.), University of Washington, Seattle.
Frank V BrozovichDepartment of Medicine, Mayo School of Medicine, Rochester, MN (F.V.B.).
Francis KimDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
David A DichekDepartments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
University of Washington · USCalifornia Institute for Regenerative Medicine · USMayo Clinic · US
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4MCARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2MReprogramming of mature smooth muscle cells to vascular progenitor cellsR01HL121877 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MARK W. MAJESKY, Mary CM Weiser-Evans · 2015 to 2026
$7.8MTransforming Growth Factor Betal and Arterial DiseaseR01HL069063 · NHLBI · UNIVERSITY OF WASHINGTON · PI DICHEK, DAVID A · 2001 to 2005
$2.2MRoles of SMC TGF-beta Signaling in Aortic Health and Aneurysm FormationR01HL116612 · NHLBI · UNIVERSITY OF WASHINGTON · PI DICHEK, DAVID A · 2013 to 2016
$1.5MNHLBI NIH HHS R01 HL069063NHLBI NIH HHS R01 HL116612NHLBI NIH HHS R01 HL121877NHLBI NIH HHS T32 HL007828NIDDK NIH HHS P30 DK017047
Abstract
[Figure: see text].
Indexed as
VasoconstrictionAnimalsAortaAortic AneurysmCell Adhesion MoleculesDilatation, PathologicEndothelium, VascularFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMuscle, Smooth, VascularMyosin Heavy ChainsNitric OxideCell Adhesion MoleculesMicrofilament Proteinsmyosin 11, mouseMyosin Heavy ChainsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mousePhosphoproteinsReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseTransforming Growth Factor betaVasodilator-Stimulated Phosphoproteinaortaendotheliummicemyographytransforming growth factor beta
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.