Evidence map›Paper›PMID 33854985›Full record

ArticleFrontiers in cellular and infection microbiology2021

The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both

Grace Huang, Kathleen Boesze-Battaglia, Lisa P Walker, Ali Zekavat, Zachary P Schaefer, Steven R Blanke, Bruce J Shenker

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Cytolethal distending toxin enhancesInfection and immunity · 2026
    Article
  2. Cytolethal Distending Toxin EnhancesbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Anti-cancer efficiency ofCytotechnology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Pathogens (Basel, Switzerland) · 2024
    Article
  9. Article
  10. LRRC8A promotesVirulence · 2023
    Article
  11. Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Frontiers in cellular and infection microbiology · 2023
    Article
  13. Revisiting bacterial cytolethal distending toxin structure and function.Frontiers in cellular and infection microbiology · 2023
    Article
  14. International journal of molecular sciences · 2022
    Article
  15. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Grace HuangDepartment of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States.
Kathleen Boesze-BattagliaDepartment of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States.
Lisa P WalkerDepartment of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States.
Ali ZekavatDepartment of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States.
Zachary P SchaeferDepartment of Microbiology, University of Illinois, Urbana, IL, United States.
Steven R BlankeDepartment of Microbiology, University of Illinois, Urbana, IL, United States.
Bruce J ShenkerDepartment of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States.
University of Pennsylvania · USUniversity of Illinois Urbana-Champaign · US

Funding

BACTERIA &LYMPHOCYTE SUPPRESSION IN PERIODONTITISR01DE006014 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI SHENKER, BRUCE J · 1985 to 2021
$8.6M
A. Actinomycetemcomitans Cdt Induces Pro-Inflammatory Innate Immune ResponsesR01DE023071 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BOESZE-BATTAGLIA, KATHLEEN, SHENKER, BRUCE J · 2013 to 2024
$4.6M
NIDCR NIH HHS R01 DE006014NIDCR NIH HHS R01 DE023071
6 · The paper itself

Abstract

Human lymphocytes exposed to

Indexed as

Campylobacter jejuniHaemophilus ducreyiBacterial ToxinsHumansPhosphatidylinositolsPhosphoric Monoester HydrolasesPolyphosphatesBacterial Toxinscytolethal distending toxinPhosphatidylinositolsPhosphoric Monoester HydrolasesPolyphosphatestriphosphoric acidapoptosiscell cycle arrestcytolethal distending toxinhost-parasite interactionslymphocytespathogenesistoxins

Identifiers

PMID33854985
PMCPMC8039388
OpenAlexW3150970321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.