Evidence map›Paper›PMID 33855053›Full record

ReviewFrontiers in cardiovascular medicine2021

Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology.

Saeideh Aghayari Sheikh Neshin, Shima Shahjouei, Eric Koza, Isabel Friedenberg, Faezeh Khodadadi, Mirna Sabra, Firas Kobeissy, Saeed Ansari, Georgios Tsivgoulis, Jiang Li and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  13. Infectious disease-associated encephalopathies.Critical care (London, England) · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 5 countries.

Saeideh Aghayari Sheikh NeshinNeuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Shima ShahjoueiNeurology Department, Neuroscience Institute, Geisinger Health System, Danville, PA, United States.
Eric KozaGeisinger Commonwealth School of Medicine, Scranton, PA, United States.
Isabel FriedenbergDepartment of Biology, Pennsylvania State University, State College, PA, United States.
Faezeh KhodadadiPES University, Bengaluru, India.
Mirna SabraNeurosciences Research Center (NRC), Lebanese University/Medical School, Beirut, Lebanon.
Firas KobeissyProgram of Neurotrauma, Neuroproteomics and Biomarker Research (NNBR), University of Florida, Gainesville, FL, United States.
Saeed AnsariNational Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, United States.
Georgios TsivgoulisSecond Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Jiang LiDepartment of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, United States.
Vida AbediDepartment of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, United States.
Donna M WolkMolecular and Microbial Diagnostics and Development, Diagnostic Medicine Institute, Laboratory Medicine, Geisinger Health System, Danville, PA, United States.
Ramin ZandNeurology Department, Neuroscience Institute, Geisinger Health System, Danville, PA, United States.
Geisinger Health System · USCommonwealth Medical College · USGeisinger Neuroscience Institute · USGuilan University of Medical Sciences · IRLebanese University · LBNational and Kapodistrian University of Athens · GRNational Institute of Neurological Disorders and Stroke · USPennsylvania State University · USPES University · INUniversity of Florida · US

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
NIA NIH HHS P30 AG072979
6 · The paper itself

Abstract

Since the early days of the pandemic, there have been several reports of cerebrovascular complications during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Numerous studies proposed a role for SARS-CoV-2 in igniting stroke. In this review, we focused on the pathoetiology of stroke among the infected patients. We pictured the results of the SARS-CoV-2 invasion to the central nervous system (CNS) via neuronal and hematogenous routes, in addition to viral infection in peripheral tissues with extensive crosstalk with the CNS. SARS-CoV-2 infection results in pro-inflammatory cytokine and chemokine release and activation of the immune system, COVID-19-associated coagulopathy, endotheliitis and vasculitis, hypoxia, imbalance in the renin-angiotensin system, and cardiovascular complications that all may lead to the incidence of stroke. Critically ill patients, those with pre-existing comorbidities and patients taking certain medications, such as drugs with elevated risk for arrhythmia or thrombophilia, are more susceptible to a stroke after SARS-CoV-2 infection. By providing a pictorial narrative review, we illustrated these associations in detail to broaden the scope of our understanding of stroke in SARS-CoV-2-infected patients. We also discussed the role of antiplatelets and anticoagulants for stroke prevention and the need for a personalized approach among patients with SARS-CoV-2 infection.

Indexed as

blood coagulationCOVID-19neuroimmunomodulationpathophysiologypharmacologyrenin-angiotensin systemSARS-CoV-2stroke

Identifiers

PMID33855053
PMCPMC8039152
OpenAlexW3152293945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.