Evidence map›Paper›PMID 33855087›Full record

ArticleJournal of diabetes research2021

Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients with Type 2 Diabetes with Preserved Ejection Fraction.

Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Daisuke Chujo, Jianhui Liu, Yuuki Shima, Azusa Ohbatake, Yukiko Miyamoto, Satoko Okazaki, Naoko Ito and 8 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Subclinical HMOD in Hypertension: Left Ventricular Diastolic Dysfunction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Kunimasa Yagi1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.ORCID https://orcid.org/0000-0002-6805-6428
Teruhiko Imamura2nd Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Hayato Tada2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Daisuke Chujo1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Jianhui Liu1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Yuuki Shima2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Azusa Ohbatake2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Yukiko Miyamoto2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Satoko Okazaki2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Naoko Ito2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Kaoru Nakano2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.
Masataka Shikata1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Asako Enkaku1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Akiko Takikawa1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Hisae Honoki1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Shiho Fujisaka1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Hideki OrigasaBiostatistics and Clinical Epidemiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 934-0194, Japan.
Kazuyuki Tobe1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
Kanazawa University · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA single-arm prospective study was conducted among Japanese patients with type 2 diabetes having preserved ejection fraction. The aim was to investigate (1) whether liraglutide therapy could improve B-type natriuretic peptide (BNP) levels and diastolic cardiac function assessed by the

methodsPatients with type 2 diabetes and left ventricular ejection fraction (LVEF) ≥ 40% without heart failure symptoms were enrolled, and daily injection with liraglutide (0.9 mg) was introduced. Cardiac functions were assessed by TTE before and after 26 weeks of liraglutide treatment. Diastolic cardiac function was defined as septal

resultsThirty-one patients were analyzed. BNP and

conclusionsLiraglutide had favorable effects on BNP and

Indexed as

AgedDiabetes Mellitus, Type 2DiastoleFemaleHumansLiraglutideMaleMiddle AgedNatriuretic Peptide, BrainStroke VolumeWeight LossLiraglutideNatriuretic Peptide, Brain

Identifiers

PMID33855087
PMCPMC8019623
OpenAlexW3140317717

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.