ArticleEndocrinology, diabetes & metabolism2021
Association between metformin and physical activity with glucose control in adults with type 2 diabetes.
Article in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial.The Journal of physiology · 2024Trial
- Association between metformin and physical activity with glucose control in adults with type 2 diabetes.Endocrinology, diabetes & metabolism · 2021Article
- Relationship Between Blood Glucose and Hemoglobin A1c Levels and Urinary Incontinence in Women.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To examine the combined association between metformin use and physical activity on HbA1c in adults with type 2 diabetes. Research Design and Methods: Adults with type 2 diabetes from NHANES continuous survey (1999-2018, n = 6447) were classified as active and inactive based on self-reported engagement in moderate-to-vigorous or vigorous physical activity (MVPA or VigPA) and metformin use over the last month. Results: There was a significant negative main effect of metformin usage on HbA1c levels, independent of whether individuals engaged in modest levels of MVPA or VigPA. Moreover, there was a higher prevalence of metformin users with a HbA1c < 6.5% than non-metformin users with no differences by activity status (36.1%-39.5% versus 24.9%-29.7%, respectively). There was a significantly lower HbA1c level ( Conclusions: There appears to be independent benefits of metformin and regular physical activity on glucose control, but the impact of these two treatments are not necessarily additive. Based on this analyses, the benefit of physical activity on HbA1c levels in type 2 diabetes is likely more apparent in those not taking metformin, as compared to those who are.
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Registered trials
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