Evidence map›Paper›PMID 33858803›Full record

Trial reportJournal of geriatric oncology2021

Caregiving burden of informal caregivers of older adults with advanced cancer: The effects of rurality and education.

Huiwen Xu, Sindhuja Kadambi, Supriya G Mohile, Shuhan Yang, Lee A Kehoe, Megan Wells, Eva Culakova, Charles Kamen, Spencer Obrecht, Mostafa Mohamed and 10 more

Registry-linked trialOpen access · greenAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Journal of geriatric oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02107443 (Improving Communication for Cancer Treatment), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02107443 nacompletednot on this map

Improving Communication for Cancer Treatment: Addressing Concerns of Older Cancer Patients and Caregivers

TypeinterventionalSponsorSupriya MohileRan2014 to 2020Enrolled546ConditionsAdult Solid Neoplasm, LymphomaArmsGeriatric Assessment Summary, Geriatric Assessment Targeted Recommendations, Geriatric Assessment (GA)
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  15. Risk factors associated with the comprehensive needs of cancer caregivers in China.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Huiwen XuDepartment of Surgery, Cancer Control, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; James P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Huiwen_XU@urmc.rochester.edu.
Sindhuja KadambiJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Sindhuja_Kadambi@URMC.Rochester.edu.
Supriya G MohileJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: supriya_mohile@urmc.rochester.edu.
Shuhan YangJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Shuhan_yang@urmc.rochester.edu.
Lee A KehoeJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Lee_Kehoe@URMC.Rochester.edu.
Megan WellsJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Megan_Wells@URMC.Rochester.edu.
Eva CulakovaDepartment of Surgery, Cancer Control, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Eva_Culakova@URMC.Rochester.edu.
Charles KamenDepartment of Surgery, Cancer Control, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Charles_Kamen@URMC.Rochester.edu.
Spencer ObrechtJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Spencer_Obrecht@URMC.Rochester.edu.
Mostafa MohamedJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Mostafa_Mohamed@URMC.Rochester.edu.
Nikesha J GilmoreDepartment of Surgery, Cancer Control, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; James P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Nikesha_Gilmore@URMC.Rochester.edu.
Allison MagnusonJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Allison_Magnuson@URMC.Rochester.edu.
Valerie Aarne GrossmanSCOREboard, Rochester, NY, USA.
Judith O HopkinsSoutheast Clinical Oncology Research Consortium, Winston-Salem, NC, USA. Electronic address: johopkins@novanthealth.org.
Jodi GeerMetro Minnesota Community Oncology Research Program, St Louis Park, MN, USA. Electronic address: jodi.geer@parknicollet.com.
Jeffrey BerenbergHawaii MU-NCORP, Honolulu, HI, USA. Electronic address: berenber@hawaii.edu.
Karen MustianDepartment of Surgery, Cancer Control, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Karen_Mustian@URMC.Rochester.edu.
Anapaula CupertinoDepartment of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Paula_Cupertino@URMC.Rochester.edu.
Nimish MohileDepartment of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Nimish_Mohile@URMC.Rochester.edu.
Kah Poh LohJames P Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: kahpoh_loh@urmc.rochester.edu.
University of Rochester Medical Center · USMetro-Minnesota Community Oncology Research Consortium · USSoutheast Clinical Oncology Research Consortium · USUniversity of Hawaii System · USUniversity of Rochester · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
The Hawaii NCORPUG1CA189804 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Jared Acoba, Jeffrey Lee Berenberg · 2014 to 2026
$15.7M
Institutional Career Development CoreKL2TR001999 · NCATS · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2016 to 2024
$5.2M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1M
Reducing Chemotherapy Toxicity in Older AdultsR01CA177592 · NCI · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2013 to 2018
$3.0M
A Patient-Oriented Research Program in Geriatric OncologyK24AG056589 · NIA · UNIVERSITY OF ROCHESTER · PI Supriya G. Mohile · 2018 to 2026
$1.5M
Mitigating Cancer-Related Cognitive Dysfunction in Older Adults with Breast CancerK76AG064394 · NIA · UNIVERSITY OF ROCHESTER · PI MAGNUSON, ALLISON MARIAN · 2019 to 2023
$1.3M
A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
A Novel Mobile Health Exercise Intervention for Older Patients with Myeloid NeoplasmsK99CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2019 to 2020
$385k
NCATS NIH HHS KL2 TR001999NCI NIH HHS K99 CA237744NCI NIH HHS R00 CA237744NCI NIH HHS R01 CA177592NCI NIH HHS UG1 CA189804NCI NIH HHS UG1 CA189961NIA NIH HHS K24 AG056589NIA NIH HHS K76 AG064394NIA NIH HHS R33 AG059206
6 · The paper itself

Abstract

objectivesRural-urban disparities in the experiences of caregivers of older adults with advanced cancer may exist. This study examined factors associated with caregiver mastery and burden and explored whether rural-urban disparities in caregiver outcomes differed by education. MATERIALS AND

methodsLongitudinal data (baseline, 4-6 weeks, and 3 months) on caregivers of older adults (≥ 70) with advanced cancer were obtained from a multicenter geriatric assessment (GA) trial (ClinicalTrials.gov: NCT02107443). Rurality was determined based on 2010 Rural-Urban Commuting Area codes. Caregivers' education was categorized as ≥ some college vs ≤ high school. Caregiver outcomes included Ryff Environmental Mastery (scored 7-35) and Caregiver Reaction Assessment (including self-esteem, disrupted schedules, financial problems, lack of social support, and health problems; each scored 1-5). Separate linear mixed models with interaction term of education and rurality were performed.

resultsOf 414 caregivers, 64 (15.5%) were from rural areas and 263 (63.5%) completed ≥ some college. Rurality was significantly associated with more disrupted schedules (β = 0.21), financial problems (β = 0.17), and lack of social support (β = 0.11). A significant interaction between education and rurality was found, with rurality associated with lower mastery (β = -1.27) and more disrupted schedule (β = 0.25), financial problems (β = 0.33), and lack of social support (β = 0.32) among caregivers with education ≤ high school.

conclusionOur study identifies subgroups of caregivers who are vulnerable to caregiving burden, specifically those from rural areas and with lower education. Multifaceted interventions are needed to improve caregivers' competency and reduce caregiving burden.

Indexed as

CaregiversNeoplasmsAgedCaregiver BurdenHumansRural PopulationSocial SupportCaregiving burdenEducationEnvironmental masteryGeriatric assessmentsRural-urban disparities

Identifiers

PMID33858803
PMCPMC8429077
OpenAlexW3156046115

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.