Evidence map›Paper›PMID 33859396›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2021

Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease.

Yoshitaka Miyaoka, Tomonari Okada, Hirofumi Tomiyama, Atsuko Morikawa, Sho Rinno, Miho Kato, Ryuji Tsujimoto, Rie Suzuki, Rieko China, Miho Nagai and 3 more

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Obesity and hypertensive renal arteriosclerosis in CKD.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  8. Review
  9. Review
  10. Update on Hypertension Research in 2021.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yoshitaka MiyaokaDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan. mitaku38@tokyo-med.ac.jp.
Tomonari OkadaDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Hirofumi TomiyamaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Atsuko MorikawaDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Sho RinnoDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Miho KatoDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Ryuji TsujimotoDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Rie SuzukiDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Rieko ChinaDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Miho NagaiDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Yume NagaokaDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Yoshihiko KannoDepartment of Nephrology, Tokyo Medical University, Tokyo, Japan.
Tokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although central hemodynamics are known to be closely associated with microvascular damage, their association with lesions in the small renal arteries has not yet been fully clarified. We focused on arterioles in renal biopsy specimens and analyzed whether their structural changes were associated with noninvasive vascular function parameters, including central blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV). Forty-four nondiabetic patients (18-50 years of age) with preserved renal function underwent renal biopsy. Wall thickening of arterioles was analyzed based on the media/diameter ratio, and hyalinosis was analyzed by semiquantitative grading. Associations of these indexes (arteriolar wall remodeling grade index (RG index) and arteriolar hyalinosis index (Hyl index)) with clinical variables were analyzed. Multiple regression analyses demonstrated that the RG index was significantly associated with central systolic BP (β = 0.97, p = 0.009), serum cystatin C-based estimated glomerular filtration rate (β = -0.36, p = 0.04), and high-density lipoprotein cholesterol levels (β = -0.37, p = 0.02). The Hyl index was significantly associated with baPWV (β = 0.75, p = 0.01). Our results indicate that aortic stiffness and abnormal central hemodynamics are closely associated with renal microvascular damage in young to middle-aged, nondiabetic kidney disease patients with preserved renal function.

Indexed as

Kidney DiseasesVascular StiffnessAnkle Brachial IndexArteriolesBlood PressureHemodynamicsHumansKidneyMiddle AgedPulse Wave AnalysisArteriolar wall remodelingArteriolosclerosisCentral blood pressurePulse wave velocityRenal biopsy

Identifiers

PMID33859396
OpenAlexW3155124725

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.