Evidence map›Paper›PMID 33861145›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Deficiency in nebulin repeats of sarcomeric nebulette is detrimental for cardiomyocyte tolerance to exercise and biomechanical stress.

Ramona M Vejandla, Buyan-Ochir Orgil, Neely R Alberson, Ning Li, Undral Munkhsaikhan, Zaza Khuchua, Ruben Martherus, Evren U Azeloglu, Fuyi Xu, Lu Lu and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Ramona M VejandlaThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Buyan-Ochir OrgilThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Neely R AlbersonThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Ning LiThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Undral MunkhsaikhanThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0002-7241-9172
Zaza KhuchuaDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ruben MartherusDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Evren U AzelogluDepartment of Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York.
Fuyi XuDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Lu LuDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Jeffrey A TowbinThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Enkhsaikhan PurevjavThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-6188-7176
University of Tennessee Health Science Center · USCincinnati Children's Hospital Medical Center · USHarbin Medical University · CNIcahn School of Medicine at Mount Sinai · USNational Research University Higher School of Economics · RUSt. Jude Children's Research Hospital · US

Funding

PEDIATRIC CARDIOMYOPATHY REGISTRYR01HL053392 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1995 to 2009
$8.3M
Prediction of Major Adverse Kidney Events and Recovery (Pred-MAKER) in COVID-19 PatientsR01DK118222 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Evren U. AZELOGLU · 2018 to 2026
$4.3M
Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
Pediatric Cardiomyopathy Specimen RepositoryR01HL087000 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TOWBIN, JEFFREY ALLEN · 2007 to 2010
$2.2M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL053392NHLBI NIH HHS R01 HL087000NHLBI NIH HHS R01 HL128350NHLBI NIH HHS R01 HL151438NIDDK NIH HHS R01 DK118222
6 · The paper itself

Abstract

The actin-binding sarcomeric nebulette (NEBL) protein provides efficient contractile flexibility via interaction with desmin intermediate filaments.

Indexed as

Actin CytoskeletonAnimalsCardiomegalyCytoskeletal ProteinsExercise ToleranceLIM Domain ProteinsMiceMice, KnockoutMyocardiumMyocytes, CardiacPhysical Conditioning, AnimalRatsSarcomeresStress, MechanicalCytoskeletal ProteinsLIM Domain ProteinsNebl protein, mousedesmin intermediate filamentexercisefocal adhesionnebulettesarcomere

Identifiers

PMID33861145
PMCPMC8163647
OpenAlexW3155104039

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.