Evidence map›Paper›PMID 33863916›Full record

ArticleNature communications2021

Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.

Qi Jia, Derek Sieburth

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  7. Hyperactive 20Science advances · 2025
    Article
  8. Article
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  10. Unlocking the Potential ofMolecules (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qi JiaPIBBS program, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8193-9786
Derek SieburthDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. sieburth@usc.edu.
University of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Stress Regulation of Synaptic TransmissionR01NS099414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEREK SIEBURTH · 2017 to 2026
$3.1M
NIEHS NIH HHS P30 ES007048NINDS NIH HHS R01 NS099414
6 · The paper itself

Abstract

Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, but a role for mitochondrial-produced ROS in regulating neurosecretion has not been described. Here we show that endogenously produced hydrogen peroxide originating from axonal mitochondria (mtH

Indexed as

Adaptation, PhysiologicalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsFeeding BehaviorGene Expression RegulationHydrogen PeroxideInterneuronsMitochondriaNeuropeptidesOxidation-ReductionOxidative StressTranscription FactorsCaenorhabditis elegans ProteinsDNA-Binding ProteinsFlp-1 protein, C elegansHydrogen PeroxideNeuropeptidesskn-1 protein, C elegansTranscription Factors

Identifiers

PMID33863916
PMCPMC8052458
OpenAlexW3154949301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.