Evidence map›Paper›PMID 33864233›Full record

ReviewStem cell reviews and reports2021

Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers.

Saravanan Ramesh, Kavitha Govarthanan, Serge Ostrovidov, Haiguang Zhang, Qingxi Hu, Gulden Camci-Unal, Rama S Verma, Murugan Ramalingam

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Direct Cardiac Reprogramming: Current Status and Future Prospects.Advances in experimental medicine and biology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Saravanan RameshSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, India.
Kavitha GovarthananStem Cell and Molecular Biology Lab, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036, India.
Serge OstrovidovCenter for Minimally Invasive Therapeutics (C-MIT), Department of Radiological Sciences, University of California, Los Angeles, CA, 90095, USA.
Haiguang ZhangRapid Manufacturing Engineering Center, Shanghai University, 200444, Shanghai, China.
Qingxi HuRapid Manufacturing Engineering Center, Shanghai University, 200444, Shanghai, China.
Gulden Camci-UnalDepartment of Chemical Engineering, University of Massachusetts Lowell, One University Ave, Lowell, MA, 01854, USA.
Rama S VermaStem Cell and Molecular Biology Lab, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036, India.
Murugan RamalingamBiomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and, Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore, 632014, India. rmurug2000@gmail.com.ORCID http://orcid.org/0000-0003-0546-0789
Indian Institute of Technology Madras · INShanghai University · CNVellore Institute of Technology University · INUniversity of California, Los Angeles · USUniversity of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disorders (CVDs) are the leading cause of global death, widely occurs due to irreparable loss of the functional cardiomyocytes. Stem cell-based therapeutic approaches, particularly the use of Mesenchymal Stem Cells (MSCs) is an emerging strategy to regenerate myocardium and thereby improving the cardiac function after myocardial infarction (MI). Most of the current approaches often employ the use of various biological and chemical factors as cues to trigger and modulate the differentiation of MSCs into the cardiac lineage. However, the recent advanced methods of using specific epigenetic modifiers and exosomes to manipulate the epigenome and molecular pathways of MSCs to modify the cardiac gene expression yield better profiled cardiomyocyte like cells in vitro. Hitherto, the role of cardiac specific inducers triggering cardiac differentiation at the cellular and molecular level is not well understood. Therefore, the current review highlights the impact and recent trends in employing biological and chemical inducers on cardiac differentiation of MSCs. Thereby, deciphering the interactions between the cellular microenvironment and the cardiac inducers will help us to understand cardiomyogenesis of MSCs. Additionally, the review also provides an insight on skeptical roles of the cell free biological factors and extracellular scaffold assisted mode for manipulation of native and transplanted stem cells towards translational cardiac research.

Indexed as

Cell DifferentiationMesenchymal Stem CellsMyocardial InfarctionMyocytes, CardiacHumansCardiac inducersCardiomyocytesExosomesGrowth factorsMesenchymal stem cellsMicroenvironmentmicro RNA

Identifiers

PMID33864233
OpenAlexW3152639973

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.