SynthesisMolecular biology reports2021
Molecular mechanisms of physical exercise on depression in the elderly: a systematic review.
Synthesis in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- The Insulin-like Growth Factor Family as a Potential Peripheral Biomarker in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Meta-analysis of the effectiveness of exercise as an intervention for suicidal tendency in depressed patients.Frontiers in psychology · 2025Pooled it
- The Effects of Various Types of Physical Exercise on Health Outcomes in Older Adults with Depression: A Systematic Review and Meta-Analysis of Controlled Trials.Depression and anxiety · 2024Pooled it
- Mechanisms Linking Physical Activity with Psychiatric Symptoms Across the Lifespan: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- META analysis on the effect of taijiquan on improving negative psychological symptoms of college students and the optimal dose.Frontiers in public health · 2022Pooled it
- Resistance training for Black men with depressive symptoms: a pilot randomized controlled trial to assess acceptability, feasibility, and preliminary efficacy.BMC psychiatry · 2022Trial
- Article
- Association between lower limb strength, anxiety, and depression symptoms in older adults.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Effects of exercise supplementary to standard therapy on cognition and sleep in depression: a randomised controlled trial.Frontiers in psychiatry · 2026Article
- Associations between muscle strength and mental health in older adults.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Molecular crosstalk for longevity: exercise and the AMPK/SIRT1/PGC-1α/Irisin/BDNF axis.Molecular biology reports · 2025Review
- Transcriptomic Insights into Late-Life Depression and the Role of Environmental Drinking Water Composition: A Study on 18-Month-Old Mice.International journal of molecular sciences · 2025Article
- Comparative Analysis of Chronic Diseases and Depression Symptoms Between Participants and Non-Participants of Physical Activity Among Chinese Older Adults in Urban and Rural Areas.Healthcare (Basel, Switzerland) · 2025Article
- Frailty trajectories and mortality risk in community-dwelling older adults: a 9-year follow-up study.European geriatric medicine · 2025Article
- Comment on "Circulating irisin levels in patients with sarcopenia: a systematic review and meta-analysis".European geriatric medicine · 2025Article
- The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression.Current issues in molecular biology · 2025Review
- Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice.Scientific reports · 2025Article
- Article
- The Mediating Role of Physical Activity and Self-Rated Health in the Association Between Depression and Quality of Life in Older Europeans: An Analysis Differentiated by Sex.Journal of clinical medicine · 2024Article
- The impact of exercise on depression: how moving makes your brain and body feel better.Physical activity and nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Depressive disorders are common among the elderly. Major depressive disorder will be one of the highest healthcare costs in middle and higher income countries by 2030. It is known that physical inactivity leads to negative effects on mental health in the elderly.The purpose of this review was to explore investigate the consequences of physical exercise (aerobic and resistance exercise) on major depressive disorder among elderly, and presenting its potential biological mechanisms. This study was designed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Clinical trials or randomized clinical trials or cohort studies participated of the study design. Ten studies were evaluated and the main outcomes of each were reported. Aerobic and resistance training revealed to be effective in fighting the symptoms of depression. The most common physical exercise protocol adopted to reduce the consequences of major depressive disorder in humans was the prescription of aerobic exercise at moderate-intensity lasting 60 min per session, 3 times per week, for 24 weeks. Physical exercise enhances IGF-I and activates PGC-1α/FNDC5/Irisin pathway. Physical exercise also increases expression of BDNF and its receptor, TrkB, in the hippocampus and prefrontal cortex leading to upstream of ERK and inhibiting depressive-like behavior. Physical exercise brings mental health benefits and plays a crucial role in avoiding the development of major depressive disorder.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.