Evidence map›Paper›PMID 33867272›Full record

ReviewTrends in immunology2021

How metabolism bridles cytotoxic CD8

Heleen H Van Acker, Shixin Ma, Tommaso Scolaro, Susan M Kaech, Massimiliano Mazzone

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. SLA2 is Associated With Immune evasion and Exhaustion of CD8Journal of cellular and molecular medicine · 2026
    Article
  6. Tumor-embedded Immunity and TRM Cell Functions in Cancer.Mini reviews in medicinal chemistry · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Prospects of molecular hydrogen in cancer prevention and treatment.Journal of cancer research and clinical oncology · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Cancer immunity and immunotherapy beyond COVID-19.Cancer immunology, immunotherapy : CII · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Heleen H Van AckerLaboratory of Tumor Inflammation and Angiogenesis, VIB - KU Leuven, Leuven, Belgium. Electronic address: Heleen.vanacker@kuleuven.be.
Shixin MaNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Tommaso ScolaroLaboratory of Tumor Inflammation and Angiogenesis, VIB - KU Leuven, Leuven, Belgium.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, VIB - KU Leuven, Leuven, Belgium. Electronic address: massimiliano.mazzone@kuleuven.be.
VIB-KU Leuven Center for Cancer Biology · BESalk Institute for Biological Studies · US

Funding

Regulation of memory CD8 T cell developmentR37AI066232 · NIAID · YALE UNIVERSITY · PI KAECH, SUSAN M · 2013 to 2022
$5.4M
Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunityR01CA240909 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2024
$3.0M
Metabolic regulation of epigenetic states in CD8 T cell exhaustionR21AI151986 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2021
$529k
NCI NIH HHS R01 CA240909NIAID NIH HHS R21 AI151986NIAID NIH HHS R37 AI066232
6 · The paper itself

Abstract

In the direct competition for metabolic resources between cancer cells and tumor-infiltrating CD8

Indexed as

CD8-Positive T-LymphocytesReceptors, Chimeric AntigenEpigenesis, GeneticReceptors, Antigen, T-CellTumor MicroenvironmentReceptors, Antigen, T-CellReceptors, Chimeric Antigen

Identifiers

PMID33867272
PMCPMC9681987
OpenAlexW3154674003

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.