Evidence map›Paper›PMID 33868582›Full record

ArticleOncotarget2021

Differential expression of Vitamin D binding protein in thyroid cancer health disparities.

Brittany Mull, Ryan Davis, Iqbal Munir, Mia C Perez, Alfred A Simental, Salma Khan

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Vitamin D-Related Genes and Thyroid Cancer-A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brittany MullHarbor UCLA Medical Center, Torrance, CA 90502, USA.
Ryan DavisDivision of Biochemistry, Loma Linda, CA 92350, USA.
Iqbal MunirRiverside University Health System, Moreno Valley, CA 92555, USA.
Mia C PerezDepartment of Pathology & Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
Alfred A SimentalDepartment of Otolaryngology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
Salma KhanDivision of Biochemistry, Loma Linda, CA 92350, USA.
Loma Linda University · USHarbor–UCLA Medical Center · USRiverside University Health System - Medical Center · US

Funding

Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2012 to 2016
$6.2M
NIMHD NIH HHS P20 MD006988
6 · The paper itself

Abstract

Thyroid cancer incidence, recurrence, and death rates are higher among Filipino Americans than European Americans. We propose that vitamin D binding protein (DBP) with multifunctionality with ethnic variability plays a key role within different ethnicities. In this study, we determined the correlation between differential DBP expression in tumor tissues and cancer staging in Filipino Americans versus European Americans. We assayed DBP expression by immunohistochemistry and analyzed the data with confocal microscopy on 200 thyroid cancer archival tissue samples obtained from both ethnicities. DBP-stable knockdown/gain-in-function assays were done by using DBP-shRNA/DBP-cDNA-expression

Indexed as

DBPhealth disparitiesthyroid cancer

Identifiers

PMID33868582
PMCPMC8021030
OpenAlexW3141333326

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.