Evidence map›Paper›PMID 33875265›Full record

ArticleSeminars in perinatology2021

Understanding how biologic and social determinants affect disparities in preterm birth and outcomes of preterm infants in the NICU.

David K Stevenson, Nima Aghaeepour, Ivana Maric, Martin S Angst, Gary L Darmstadt, Maurice L Druzin, Brice Gaudilliere, Xuefeng B Ling, Mira N Moufarrej, Laura S Peterson and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

David K StevensonDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA. Electronic address: dstevenson@stanford.edu.
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School ofMedicine, Stanford, CA 94305, USA.
Ivana MaricDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA.
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School ofMedicine, Stanford, CA 94305, USA.
Gary L DarmstadtDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA.
Maurice L DruzinDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School ofMedicine, Stanford, CA 94305, USA.
Xuefeng B LingDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Palo Alto, CA 94306, USA.
Mira N MoufarrejDepartment of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA.
Laura S PetersonDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA.
Stephen R QuakeDepartment of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA.
David A RelmanDepartment of Medicine, Stanford University School of Medicine and the Chan Zuckerberg Biohub Stanford, CA 94305, USA; Infectious Diseases Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Michael P SnyderStanford Center for Genomics and Personalized Medicine, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Karl G SylvesterDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gary M ShawDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA.
Ronald J WongDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 1265 Welch Rd, X157, Stanford, CA 94305-5415, USA.
Stanford University · USChan Zuckerberg Initiative (United States) · US

Funding

Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2M
NIGMS NIH HHS R35 GM138353
6 · The paper itself

Abstract

To understand the disparities in spontaneous preterm birth (sPTB) and/or its outcomes, biologic and social determinants as well as healthcare practice (such as those in neonatal intensive care units) should be considered. Disparities in sPTB have been largely intractable and remain obscure in most cases, despite a myriad of identified risk factors for and causes of sPTB. We still do not know how they lead to the different outcomes at different gestational ages and if they are independent of NICU practices. Here we describe an integrated approach to study the interplay between the genome and exposome, which may drive biochemistry and physiology and lead to health disparities.

Indexed as

Biological ProductsPremature BirthFemaleHumansInfantInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalPregnancySocial Determinants of HealthBiological Products

Identifiers

PMID33875265
PMCPMC9159791
OpenAlexW3138217476

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.