Evidence map›Paper›PMID 33879721›Full record

ArticleMedicine2021

Study on the effectiveness and safety of Xingpi Yanger granule combined with Saccharomyces boulardii for rotavirus enteritis in children: A protocol for systematic review and meta-analysis.

Cheng-Ying Qiu, Zao-Xia Guo, Gui-Hua Zhang, Yong-Hong Feng, Ying-Yun Deng, Xian-Jia Chen, Xiao-Dong Wu, Shan-Wen Huang

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The complete chloroplast genome sequence ofMitochondrial DNA. Part B, Resources · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cheng-Ying QiuDepartment of Pediatrics, Sanya People 's Hospital, No. 558 Jiefang Road, Tianya District, Sanya City.
Zao-Xia GuoDepartment of Internal Medicine of Traditional Chinese Medicine, Danzhou Hospital of Traditional Chinese Medicine, No. 30-20 Zhongxing Avenue, Danzhou City.
Gui-Hua ZhangDepartment of Neonatology, Haikou Hospital of the Matemal and Child Health, NO.6 Wentan Road, Guoxing Avenue, Qiongshan District, Haikou City.
Yong-Hong FengDepartment of Neonatology, Haikou Hospital of the Matemal and Child Health, NO.6 Wentan Road, Guoxing Avenue, Qiongshan District, Haikou City.
Ying-Yun DengDepartment of Pediatrics, Sanya People 's Hospital, No. 558 Jiefang Road, Tianya District, Sanya City.
Xian-Jia ChenDepartment of Spleen-Stomach Diseases, Danzhou Hospital of Traditional Chinese Medicine, No. 30-20 Zhongxing Avenue, Danzhou City.
Xiao-Dong WuDepartment of Geriatrics, Danzhou Hospital of Traditional Chinese Medicine, No. 30-20 Zhongxing Avenue, Danzhou City.
Shan-Wen HuangDepartment of Pediatrics, Haikou Hospital of the Matemal and Child Health, NO.6 Wentan Road, Guoxing Avenue, Qiongshan District, Haikou City, Hainan Province, China.ORCID 0000-0002-3240-665
S.P.E.C.I.E.S. · USSanya Central Hospital · CNHaikou City People's Hospital · CN

Funding

Hainan Province Scientific Research Projects of Health and Family Planning Industry No. 18A200134
6 · The paper itself

Abstract

backgroundTo systematically evaluate the effectiveness and safety of traditional Chinese medicine preparation XPYEG combined with SBI and SBI alone in the treatment of REC, and to provide the reference in drugs for the clinical treatment of children with rotavirus enteritis.

methodsRetrieving the English databases: PubMed, Cochrane Library and Embase; Chinese databases: CNKI, CBM and WANFANG Data. Retrieving a randomized controlled trial of XPYEG and SBI in the treatment of REC. The retrieval time is from the above database until September 2020. The retrieval strategy of combining free words and subject words is adopted, and the references included in the literature are searched manually in accordance with the literature studied in this paper and not included in the above database. Two researchers screen the literature according to the literature inclusion and exclusion criteria, extract valid data and evaluate the quality of the literature, and cross-check it. Using the RevMan 5.3 software to conduct the meta-analysis on the main outcome and secondary outcome indicators of the included literature, while assessing the evidence quality of included study.

resultsThe effectiveness and safety of XPYEG and SBI in the treatment of REC are presented through the main and secondary outcome indicators. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/3QSZG.

conclusionThis study will conclude whether the combination of XPYEG and SBI is more effective than SBI alone in the treatment of REC, and whether the medication increases the risk of adverse reactions compared with single medication. ETHICS AND DISSEMINATION: This study does not involve the specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.

Indexed as

Saccharomyces boulardiiChild, PreschoolDrugs, Chinese HerbalEnteritisFemaleHumansInfantMaleMeta-Analysis as TopicProbioticsRandomized Controlled Trials as TopicResearch DesignRotavirus InfectionsSystematic Reviews as TopicTreatment OutcomeDrugs, Chinese Herbal

Identifiers

PMID33879721
PMCPMC8078475
OpenAlexW3153506256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.