SynthesisJournal of medical Internet research2021
Role of Artificial Intelligence Applications in Real-Life Clinical Practice: Systematic Review.
Synthesis in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 17 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
177 citing papers in PubMed, 17 syntheses or guidelines pooled it.
- Machine learning prediction models for intravenous immunoglobulin resistance in Kawasaki disease: a meta-analysis.BMC medical informatics and decision making · 2026Pooled it
- Facilitators and Barriers to Implementing AI in Routine Medical Imaging: Systematic Review and Qualitative Analysis.Journal of medical Internet research · 2025Pooled it
- Healthcare professionals' perspectives on artificial intelligence in patient care: a systematic review of hindering and facilitating factors on different levels.BMC health services research · 2025Pooled it
- Machine learning and artificial intelligence in type 2 diabetes prediction: a comprehensive 33-year bibliometric and literature analysis.Frontiers in digital health · 2025Pooled it
- Artificial intelligence in the prevention and early detection of postpartum depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Artificial Intelligence (AI) and Healthcare Capabilities: A Systematic Review and Research Directions.F1000Research · 2025Pooled it
- Artificial intelligence in risk prediction and diagnosis of vertebral fractures.Scientific reports · 2024Pooled it
- Implementation of Machine Learning Applications in Health Care Organizations: Systematic Review of Empirical Studies.Journal of medical Internet research · 2024Pooled it
- Implementing AI in Hospitals to Achieve a Learning Health System: Systematic Review of Current Enablers and Barriers.Journal of medical Internet research · 2024Pooled it
- The usefulness of artificial intelligence in breast reconstruction: a systematic review.Breast cancer (Tokyo, Japan) · 2024Pooled it
- AI Quality Standards in Health Care: Rapid Umbrella Review.Journal of medical Internet research · 2024Pooled it
- Impact of Artificial Intelligence-Based Technology on Nurse Management: A Systematic Review.Journal of nursing management · 2024Pooled it
- Deployment of machine learning algorithms to predict sepsis: systematic review and application of the SALIENT clinical AI implementation framework.Journal of the American Medical Informatics Association : JAMIA · 2023Pooled it
- Pooled it
- Stakeholder Perspectives of Clinical Artificial Intelligence Implementation: Systematic Review of Qualitative Evidence.Journal of medical Internet research · 2023Pooled it
- Randomized Controlled Trials of Artificial Intelligence in Clinical Practice: Systematic Review.Journal of medical Internet research · 2022Pooled it
- Distinguish the Value of the Benign Nevus and Melanomas Using Machine Learning: A Meta-Analysis and Systematic Review.Mediators of inflammation · 2022Pooled it
- A cognitive layer architecture to support large-language model performance in psychotherapy interactions.Nature medicine · 2026Trial
- Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial.Journal of the American Medical Informatics Association : JAMIA · 2024Trial
- Real-Time AI-Augmented Fluoroscopic Navigation for Intraoperative Pulmonary Nodule Localization: Prospective Observational Pilot Study.JMIR formative research · 2026Observational
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArtificial intelligence (AI) applications are growing at an unprecedented pace in health care, including disease diagnosis, triage or screening, risk analysis, surgical operations, and so forth. Despite a great deal of research in the development and validation of health care AI, only few applications have been actually implemented at the frontlines of clinical practice.
objectiveThe objective of this study was to systematically review AI applications that have been implemented in real-life clinical practice.
methodsWe conducted a literature search in PubMed, Embase, Cochrane Central, and CINAHL to identify relevant articles published between January 2010 and May 2020. We also hand searched premier computer science journals and conferences as well as registered clinical trials. Studies were included if they reported AI applications that had been implemented in real-world clinical settings.
resultsWe identified 51 relevant studies that reported the implementation and evaluation of AI applications in clinical practice, of which 13 adopted a randomized controlled trial design and eight adopted an experimental design. The AI applications targeted various clinical tasks, such as screening or triage (n=16), disease diagnosis (n=16), risk analysis (n=14), and treatment (n=7). The most commonly addressed diseases and conditions were sepsis (n=6), breast cancer (n=5), diabetic retinopathy (n=4), and polyp and adenoma (n=4). Regarding the evaluation outcomes, we found that 26 studies examined the performance of AI applications in clinical settings, 33 studies examined the effect of AI applications on clinician outcomes, 14 studies examined the effect on patient outcomes, and one study examined the economic impact associated with AI implementation.
conclusionsThis review indicates that research on the clinical implementation of AI applications is still at an early stage despite the great potential. More research needs to assess the benefits and challenges associated with clinical AI applications through a more rigorous methodology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.