Evidence map›Paper›PMID 33889172›Full record

ArticleFrontiers in genetics2021

Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach.

Naaila Tamkeen, Suliman Yousef AlOmar, Saeed Awad M Alqahtani, Abdullah Al-Jurayyan, Anam Farooqui, Safia Tazyeen, Nadeem Ahmad, Romana Ishrat

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In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naaila TamkeenDepartment of Biosciences, Jamia Millia Islamia, New Delhi, India.
Suliman Yousef AlOmarDoping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Saeed Awad M AlqahtaniDepartment of Physiology, Faculty of Medicine, Taibah University, Medina, Saudi Arabia.
Abdullah Al-JurayyanImmunology and HLA Section, Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
Anam FarooquiCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Safia TazyeenCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Nadeem AhmadDepartment of Biosciences, Jamia Millia Islamia, New Delhi, India.
Romana IshratCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spina Bifida (SB) is a congenital spinal cord malformation. Efforts to discern the key regulators (KRs) of the SB protein-protein interaction (PPI) network are requisite for developing its successful interventions. The architecture of the SB network, constructed from 117 manually curated genes was found to self-organize into a scale-free fractal state having a weak hierarchical organization. We identified three modules/motifs consisting of ten KRs, namely,

Indexed as

key regulatorsprotein-protein interaction networkrich-club analysisSpina bifidatopological analysis

Identifiers

PMID33889172
PMCPMC8056047

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.