Evidence map›Paper›PMID 33890574›Full record

ArticleeLife2021

Co-regulation and function of

Carter J Barger, Linda Chee, Mustafa Albahrani, Catalina Munoz-Trujillo, Lidia Boghean, Connor Branick, Kunle Odunsi, Ronny Drapkin, Lee Zou, Adam R Karpf

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Article
  9. Article
  10. Article
  11. Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Molecular models of bidirectional promoter regulation.Current opinion in structural biology · 2024
    Review
  16. Article
  17. PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carter J BargerEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Linda CheeEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Mustafa AlbahraniEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Catalina Munoz-TrujilloEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Lidia BogheanEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Connor BranickEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.
Kunle OdunsiDepartments of Gynecologic Oncology, Immunology, and Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, United States.
Ronny DrapkinPenn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Lee ZouMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, United States.
Adam R KarpfEppley Institute for Cancer Research and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, United States.ORCID 0000-0002-0866-0666
University of Nebraska Medical Center · USCancer Research Center · USHarvard University · USRoswell Park Comprehensive Cancer Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
SPORE in Ovarian CancerP50CA228991 · NCI · JOHNS HOPKINS UNIVERSITY · PI Amanda Nickles Fader · 2018 to 2026
$20.5M
CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
FOXM1-RHNO1 Oncogenic Axis in Ovarian CancerF99CA212470 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BARGER, CARTER J · 2016 to 2017
$65k
NCI NIH HHS F99 CA212470NCI NIH HHS P30 CA036727NCI NIH HHS P50 CA228991NCI NIH HHS T32 CA009476
6 · The paper itself

Abstract

The FOXM1 transcription factor is an oncoprotein and a top biomarker of poor prognosis in human cancer. Overexpression and activation of FOXM1 is frequent in high-grade serous carcinoma (HGSC), the most common and lethal form of human ovarian cancer, and is linked to copy number gains at chromosome 12p13.33. We show that

Indexed as

Gene Expression Regulation, NeoplasticAtaxia Telangiectasia Mutated ProteinsCarboplatinCarrier ProteinsCell Line, TumorCell ProliferationCheckpoint Kinase 1Databases, GeneticDrug Resistance, NeoplasmFemaleForkhead Box Protein M1HumansNeoplasms, Cystic, Mucinous, and SerousOvarian NeoplasmsPoly(ADP-ribose) Polymerase InhibitorsPromoter Regions, GeneticAtaxia Telangiectasia Mutated ProteinsATR protein, humanCarboplatinCarrier ProteinsCheckpoint Kinase 1CHEK1 protein, humanForkhead Box Protein M1FOXM1 protein, humanPoly(ADP-ribose) Polymerase InhibitorsRHNO1 protein, humanbidirectional genescancer biologychromosomesDNA repairFOXM1gene expressionhumanovarian cancerPARP inhibitorsRHNO1

Identifiers

PMID33890574
PMCPMC8104967
OpenAlexW3156711859

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.