Evidence map›Paper›PMID 33891207›Full record

SynthesisArchives of gynecology and obstetrics2021

Polymorphisms of vascular endothelial growth factor and recurrent implantation failure: a systematic review and meta-analysis.

Hong Zeng, Lian Hu, Hebin Xie, Wenmin Ma, Song Quan

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Divergent Associations of the VEGF (Medicina (Kaunas, Lithuania) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Biomolecular Markers of Recurrent Implantation Failure-A Review.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Hong ZengFoshan Maternal and Child Health Care Hospital of Southern Medical University, Foshan, 528000, Guangdong, China.ORCID http://orcid.org/0000-0003-0216-8117
Lian HuDepartment of Gynecology and Obstetrics, Changsha Fourth Hospital, Changsha, 410006, China.
Hebin XieChangsha Central Hospital of Nanhua University, Changsha, 410004, Hunan, China.
Wenmin MaFoshan Maternal and Child Health Care Hospital of Southern Medical University, Foshan, 528000, Guangdong, China. mwm341@sohu.com.
Song QuanDepartment of Reproductive Medicine Center, NanFang Hospital of Southern Medical University, Guangzhou, 510000, Guangdong, China. quansong@smu.edu.cn.
Foshan Maternity and Child Health Care Hospital · CNChangsha Central Hospital · CNFourth Hospital of Changsha · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the associations between polymorphisms of vascular endothelial growth factor (VEGF) with recurrent implantation failure (RIF).

methodsWe performed the systematic review and meta-analysis by searching databases of PubMed, EMBASE, OVID, and CNKI (China National Knowledge Infrastructure) for studies that evaluated the associations between VEGF polymorphisms with RIF. Meta-analysis was performed if the polymorphism was studied by more than two case-control studies. Data were analyzed using R software. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported to assess the associations.

resultsNine VEGF polymorphisms (-1154G > A, -460T > C, +405G > C, -7C > T, -634C > G, -2578C > A, +936C > T, 5C > T, -583C > T) were systematically reviewed. Meta-analysis was performed on VEGF -1154 G > A polymorphism. Three case-control studies consisted of 683 women were included in the quantitative meta-analysis (305 RIF patients and 378 controls). Results showed that VEGF -1154A allele was significantly associated with RIF (OR 1.39, 95% CI 1.08-1.78, P-value = 0.01). The dominant genetic model showed that VEGF 1154AA plus VEGF 1154AG genotypes were more frequent in RIF patients than VEGF 1154GG genotype (OR 1.56, 95% CI 1.10-2.20, P-value = 0.01). However, the result under the recessive genetic model showed no significant difference (OR 1.67, 95% CI 0.92-3.03, P-value = 0.09).

conclusionVEGF -1154A allele may serve as one of the predisposing factors of RIF. Women with VEGF 1154 AA/GA genotypes were at higher risk of RIF. However, we should consider the haplotype effect of VEGF polymorphisms in future studies.

Indexed as

Embryo ImplantationGenetic Predisposition to DiseaseFemaleGenotypeHumansPolymorphism, Single NucleotideVascular Endothelial Growth FactorsVascular Endothelial Growth FactorsGenetic polymorphismMeta-analysisRecurrent implantation failureSystematic reviewVascular endothelial growth factor

Identifiers

PMID33891207
OpenAlexW3154557240

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.