Evidence map›Paper›PMID 33891950›Full record

ArticleNeuropharmacology2021

Activation of V

Saobo Lei, Binqi Hu, Neda Rezagholizadeh

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Saobo LeiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA. Electronic address: saobo.lei@und.edu.
Binqi HuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Neda RezagholizadehDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
University of North Dakota · US

Funding

Cellular and molecular mechanisms of vasopressin in anxietyR01MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2023
$1.5M
NIMH NIH HHS R01 MH118258
6 · The paper itself

Abstract

Arginine vasopressin (AVP) is a nonapeptide that serves as a neuromodulator in the brain and a hormone in the periphery that regulates water homeostasis and vasoconstriction. The subiculum is the major output region of the hippocampus and an integral component in the networks that processes sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information. Whereas the subiculum expresses high densities of AVP-binding sites and AVP has been shown to increase the synaptic excitability of subicular pyramidal neurons, the underlying cellular and molecular mechanisms have not been determined. We found that activation of V

Indexed as

Action PotentialsAnimalsArginine VasopressinCalciumG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHippocampusMembrane PotentialsMiceMice, KnockoutPatch-Clamp TechniquesPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaPyramidal CellsReceptors, VasopressinTRPV Cation ChannelsVasoconstrictor AgentsArginine VasopressinAVPR1a receptor, mouseCalciumG Protein-Coupled Inwardly-Rectifying Potassium ChannelsPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaReceptors, VasopressinTRPV1 protein, mouseTRPV Cation ChannelsVasoconstrictor AgentsAction potentialCation channelExcitabilityG proteinK(+) channelsPeptideReceptorSubiculumSynapse

Identifiers

PMID33891950
PMCPMC8169586
OpenAlexW3153902380

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.