Sexually Dimorphic Role of Toll-like Receptor 4 (TLR4) in High Molecular Weight Hyaluronan (HMWH)-induced Anti-hyperalgesia.

Ivan J M Bonet, Dionéia Araldi, Paul G Green, Jon D Levine

Open access · greenAbstract read

In one paragraph

Article in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.7field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

G-protein-coupled estrogen receptor 30 regulation of signaling downstream of protein kinase Cε mediates sex dimorphism in hyaluronan-induced antihyperalgesia.Pain · 2025
Article
A novel potential strategy for the treatment of inflammatory and neuropathic pain.Pain · 2023
Article
Action of Hyaluronic Acid as a Damage-Associated Molecular Pattern Molecule and Its Function on the Treatment of Temporomandibular Disorders.Frontiers in pain research (Lausanne, Switzerland) · 2022
Review
Precision Exercise Medicine: Sex Specific Differences in Immune and CNS Responses to Physical Activity.Brain plasticity (Amsterdam, Netherlands) · 2022
Review
Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice.Brain, behavior, and immunity · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ivan J M BonetDepartments of Medicine and Oral & Maxillofacial Surgery, San Francisco; UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco.

Dionéia AraldiDepartments of Medicine and Oral & Maxillofacial Surgery, San Francisco; UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco.

Paul G GreenDepartments of Medicine and Oral & Maxillofacial Surgery, San Francisco; UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco; Departments of Preventative and Restorative Dental Sciences, University of California at San Francisco, San Francisco.

Jon D LevineDepartments of Medicine and Oral & Maxillofacial Surgery, San Francisco; UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco; Departments of Medicine, University of California at San Francisco, San Francisco. Electronic address: Jon.Levine@ucsf.edu.

University of California, San Francisco · US

Funding

Hyaluronan signaling to nociceptors in inflammatory painR01AR075334 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023

$3.0M

NIAMS NIH HHS R01 AR075334

6 · The paper itself

Abstract

High molecular weight hyaluronan (HMWH), a prominent component of the extracellular matrix binds to and signals via multiple receptors, including cluster of differentiation 44 (CD44) and toll-like receptor 4 (TLR4). We tested the hypothesis that, in the setting of inflammation, HMWH acts at TLR4 to attenuate hyperalgesia. We found that the attenuation of prostaglandin E

Indexed as

Sex CharacteristicsAdjuvants, ImmunologicAnimalsDinoprostoneDisease Models, AnimalFemaleHyaluronic AcidHyperalgesiaMaleMolecular WeightMyeloid Differentiation Factor 88OvariectomyRatsSignal TransductionToll-Like Receptor 4Adjuvants, ImmunologicDinoprostoneHyaluronic AcidMyd88 protein, ratMyeloid Differentiation Factor 88Tlr4 protein, ratToll-Like Receptor 4anti-hyperalgesiahigh molecular weight hyaluronan (HMWH)hyaluronanHyperalgesiaprostaglandin E(2) (PGE(2))toll-like receptor 4 (TLR4)

Identifiers

PMID33892155

DOI10.1016/j.jpain.2021.03.152

PMCPMC8500912

OpenAlexW3153854471

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.