Evidence map›Paper›PMID 33893069›Full record

ReviewRedox biology2021

Redox regulation of the insulin signalling pathway.

Claudia Lennicke, Helena M Cochemé

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 99 citations in OpenAlex.

  1. Flavonoids fromJournal of enzyme inhibition and medicinal chemistry · 2026
    Article
  2. Review
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  5. Proteoforms as the true units of physiological function.European journal of applied physiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Claudia LennickeMRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Helena M CocheméMRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. Electronic address: helena.cocheme@lms.mrc.ac.uk.
Hammersmith Hospital · GBImperial College London · GB

Funding

Medical Research Council MC-A654-5QB90Medical Research Council MC_UP_1102/10
6 · The paper itself

Abstract

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which mediates fundamental cellular responses. Oxidants, in particular H

Indexed as

InsulinPhosphatidylinositol 3-KinasesAnimalsHumansHydrogen PeroxideOxidation-ReductionSignal TransductionHydrogen PeroxideInsulinPhosphatidylinositol 3-KinasesCysteine post-translational modificationFOXOH(2)O(2)Insulin signallingNRF2Redox regulationROSType-2 diabetes

Identifiers

PMID33893069
PMCPMC8113030
OpenAlexW3144125154

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.