ArticleNature communications2021
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Mechanistic Investigation of Exercise Interventions in Rodent Models of Alzheimer's Disease and Prospects for Clinical Translation.Neural plasticity · 2026Pooled it
- Metabolic Shifts Precede Cognitive Decline in the Male hAß-KI Alzheimer's Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
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- Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model.Acta neuropathologica · 2026Article
- Tracer Techniques in Ophthalmology: Ocular Applications and Systemic Connections.Diagnostics (Basel, Switzerland) · 2026Review
- Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Abi3Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- PSEN1 mutant marmoset fibroblasts mimic multi-omic signatures of Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Type-1 interferons associated with microglial-mediated neuroinflammation in Alzheimer's disease.Journal of neuroinflammation · 2026Review
- Mitochondrial ecosystem restoration in Alzheimer's disease: from mechanisms to multi-target therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
- Exploring neuroprotective effects of Chuanzhitongluo capsule on an alzheimer's disease rat model.Metabolic brain disease · 2025Article
- Integrative gene co-expression network analysis reveals protein-coding and LncRNA genes associated with Alzheimer's disease pathology.Scientific reports · 2025Article
- MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.Acta neuropathologica communications · 2025Article
- Young adult microglial deletion of C1q reduces engulfment of synapses and prevents cognitive impairment in an aggressive Alzheimer's disease mouse model.bioRxiv : the preprint server for biology · 2025Article
- Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice.Aging cell · 2025Article
- Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- An update on mammalian and non-mammalian animal models for biomarker development in neurodegenerative disorders.Cellular and molecular life sciences : CMLS · 2025Review
- Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- EBP1 potentiates amyloid β pathology by regulating γ-secretase.Nature aging · 2025Article
- Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models.Scientific reports · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 3 institutions in 2 countries.
David Baglietto-VargasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0003-1441-3175
Stefania FornerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0001-7977-4866
Lena CaiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Alessandra C MartiniInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0002-8447-6756
Laura Trujillo-EstradaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Vivek SwarupInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0003-3762-2746
Marie Minh Thu NguyenInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Kelly Do HuynhInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Dominic I JavonilloInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Kristine Minh TranInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Jimmy PhanInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Shan JiangDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Enikö A KramárInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Cristina Nuñez-DiazDepartment of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain.
Gabriela Balderrama-GutierrezDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Franklin GarciaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0002-3949-9633
Jessica ChildsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Carlos J Rodriguez-OrtizInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0003-2688-947X
Juan Antonio Garcia-LeonDepartment of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain.
Masashi KitazawaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0003-2165-8197
Mohammad ShahnawazThe Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Dina P MatheosInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Xinyi MaDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Ken C WallsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Rahasson R AgerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Claudio SotoThe Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Antonia GutierrezDepartment of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain.ORCID 0000-0002-6264-6152
Ines Moreno-GonzalezDepartment of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain.ORCID 0000-0003-3875-0889
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-4259-6362
Andrea J TennerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.ORCID 0000-0003-3000-024X
Grant R MacGregorDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0001-7598-9501
Marcelo WoodInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Kim N GreenInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. kngreen@uci.edu.ORCID 0000-0002-6049-6744
Frank M LaFerlaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. laferla@uci.edu.ORCID 0000-0003-2324-6911
University of California, Irvine · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESThe University of Texas Health Science Center at Houston · US
Funding
UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FRANK M LAFERLA · 2017 to 2026
$71.9MUniv.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MUC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0MTISSUE REPOSITORY COREP01AG000538 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 1985 to 2018
$24.8MOrigins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brainR01NS083801 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2014 to 2026
$5.6MLearning and Memory Impairments in Transgenic AD ModelsR01AG027544 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2007 to 2016
$3.1MMicroglia are necessary for cortical plaque formation in Alzheimer's diseaseRF1AG056768 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GREEN, KIM · 2018 to 2018
$2.7MBlood-based diagnostics for Alzheimer's DiseaseR42AG049562 · NIA · AMPRION, INC. · PI SOTO, CLAUDIO, VOLLRATH, BEN · 2015 to 2017
$1.3MThe impact of endocytic protein Tom1 on Alzheimer's diseaseR21AG054884 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2016 to 2017
$425kA Neurolucida and Stereo Investigator Imaging System with MicroLucidaS10OD010420 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2012 to 2012
$311kNCI NIH HHS P30 CA062203NIA NIH HHS P01 AG000538NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG027544NIA NIH HHS R21 AG054884NIA NIH HHS R42 AG049562NIA NIH HHS RF1 AG056768NIA NIH HHS U54 AG054349NIH HHS S10 OD010420NINDS NIH HHS R01 NS083801
Abstract
The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. Remarkably, changing 3 amino acids in the mouse Aβ sequence to its wild-type human counterpart leads to age-dependent impairments in cognition and synaptic plasticity, brain volumetric changes, inflammatory alterations, the appearance of Periodic Acid-Schiff (PAS) granules and changes in gene expression. In addition, when exon 14 encoding the Aβ sequence was flanked by loxP sites we show that Cre-mediated excision of exon 14 ablates hAβ expression, rescues cognition and reduces the formation of PAS granules.
Indexed as
Disease Models, AnimalMutationAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainFemaleGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein Precursor
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What Socratic holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.