ReviewGenes, brain, and behavior2021
Integration of evidence across human and model organism studies: A meeting report.
Open access · hybridAbstract readReview
In one paragraph
Review in Genes, brain, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use.Translational psychiatry · 2026Article
- Differing Genetics of Saline and Cocaine Self-Administration in the Hybrid Mouse Diversity Panel.Genes, brain, and behavior · 2025Article
- Differing genetics of saline and cocaine self-administration in the hybrid mouse diversity panel.bioRxiv : the preprint server for biology · 2025Article
- RatXcan: A framework for cross-species integration of genome-wide association and gene expression data.PLoS genetics · 2025Article
- A cost-effective, high-throughput, highly accurate genotyping method for outbred populations.G3 (Bethesda, Md.) · 2025Article
- Influence of multi-species data on gene-disease associations in substance use disorder using random walk with restart models.PloS one · 2025Article
- A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations.bioRxiv : the preprint server for biology · 2024Article
- Multi-omics cannot replace sample size in genome-wide association studies.Genes, brain, and behavior · 2023Article
- Spaceflight Induces Strength Decline inCells · 2023Article
- Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice.Cell reports · 2023Article
- Gene expression genetics of the striatum of Diversity Outbred mice.bioRxiv : the preprint server for biology · 2023Article
- Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Integration of evidence across human and model organism studies: A meeting report.Genes, brain, and behavior · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 20 institutions in 2 countries.
Rohan H C PalmerBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6809-9962
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-0394-777X
Hyejung WonDepartment of Genetics and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0003-3651-0566
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-0745-6046
Manav KapoorNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-6682-940X
Apurva ChitreDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-1709-9214
Molly A BogueThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID https://orcid.org/0000-0001-6624-9261
Chelsie E Benca-BachmanBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-5372-4593
Clarissa C ParkerDepartment of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Anurag VermaBiomedical and Translational Informatics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5063-9107
Timothy ReynoldsThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID https://orcid.org/0000-0003-2534-5462
Jason ErnstDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-4026-7853
Michael BrayDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Soo Bin KwonDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8670-0993
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0001-7803-580X
Bryan C QuachGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0002-1094-3104
Nathan C GaddisGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0001-5205-7138
Laura SabaDepartment of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0001-9649-1294
Hao ChenDepartment of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Michael HawrylyczAllen Institute, Seattle, Washington, USA.
Shan ZhangDepartment of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
Yuan ZhouDepartment of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
Spencer MahaffeyDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0001-7035-9930
Christian FischerDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0001-6137-5699
Anita BandrowskiDepartment of Neuroscience, University of California, San Diego, La Jolla, California, USA.
Qing LuDepartment of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
Li ShenNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Vivek PhilipThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID https://orcid.org/0000-0001-5126-707X
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-4067-1859
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-9952-4810
Dana B HancockGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.ORCID https://orcid.org/0000-0003-2240-3604
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0003-0344-9690
Eric O JohnsonGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
Eric J NestlerNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-7905-2000
Peter B BarrDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0001-9321-657X
Pjotr PrinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-8021-9162
Desmond J SmithDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Schahram AkbarianFriedman Brain Institute and Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-7700-0891
Thorgeir ThorgeirssondeCODE Genetics/Amgen Inc., Reykjavik, Iceland.ORCID https://orcid.org/0000-0002-5149-7040
Dave WaltonThe Jackson Laboratory, Bar Harbor, Maine, USA.
Erich BakerDepartment of Computer Science, Baylor University, Waco, Texas, USA.ORCID https://orcid.org/0000-0002-7798-5704
Daniel JacobsonComputational and Predictive Biology, Biosciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.ORCID https://orcid.org/0000-0002-9822-8251
Abraham A PalmerDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-3634-0747
Michael MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-1532-584X
Elissa J CheslerThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID https://orcid.org/0000-0002-5642-5062
Jake EmersonThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID https://orcid.org/0000-0003-0617-9219
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-0313-793X
Maryann MartoneDepartment of Neuroscience, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-8406-3871
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jackson Laboratory · USRTI International · USUniversity of California San Diego · USAllen Institute for Brain Science · USUniversity of Tennessee Health Science Center · USUniversity of California, Los Angeles · USWashington University in St. Louis · USEmory University · USIndiana University School of MedicineUniversity of Florida Health · USVirginia Commonwealth University · USYale University · USAllen Institute · USBaylor University · USdeCODE Genetics (Iceland) · ISMichigan State University · USMiddlebury College · USOak Ridge National Laboratory · USTranslational Therapeutics (United States) · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI MEYER, PAUL J · 2014 to 2023
$27.4MThe Heritable Transcriptome and AlcoholismR24AA013162 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HOFFMAN, PAULA, SABA, LAURA MAREN · 2001 to 2021
$14.2MMouse Phenome ProjectR01DA028420 · NIDA · JACKSON LABORATORY · PI Elissa J Chesler · 2010 to 2026
$9.5MNJ Methadone Maintenance Subject Recruitment for Genomic Analyses and Repository ExpansionR01DA044014 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2017 to 2021
$4.2MTIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2017 to 2021
$3.9MFunctional genomic resource and integrative model of dopaminergic circuitry associated with psychiatric diseaseU01DA048279 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2019 to 2023
$3.5MGene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.R01DA051908 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JACOBSON, DANIEL A, JOHNSON, ERIC OTTO · 2020 to 2024
$3.4M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MGenetic pathways for impulsivity and drug reinforcement: DNA and transcriptome variation in miceU01DA041602 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR, JENTSCH, J. DAVID · 2017 to 2021
$3.2MSystem genetics of menthol and nicotine addictionU01DA047638 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHEN, HAO, WILLIAMS, ROBERT W. · 2019 to 2023
$3.1M7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1MNCATS NIH HHS UL1 TR001863NIAAA NIH HHS R24 AA013162NIDA NIH HHS DA028420NIDA NIH HHS DA032573NIDA NIH HHS DA037844NIDA NIH HHS DA039832NIDA NIH HHS DA041602NIDA NIH HHS DA041618NIDA NIH HHS DA042103NIDA NIH HHS DA044223NIDA NIH HHS DA044371NIDA NIH HHS DA045401NIDA NIH HHS DA047527NIDA NIH HHS DA048279NIDA NIH HHS DA051908NIDA NIH HHS DA051913NIDA NIH HHS DA051921NIDA NIH HHS DP1 DA042103NIDA NIH HHS DP1 DA044371NIDA NIH HHS K02 DA032573NIDA NIH HHS P30 DA044223NIDA NIH HHS P50 DA037844NIDA NIH HHS R01 DA028420NIDA NIH HHS R01 DA044014NIDA NIH HHS R01 DA045401NIDA NIH HHS R01 DA051908NIDA NIH HHS R01 DA051913NIDA NIH HHS R01 DA054869NIDA NIH HHS R15 DA041618NIDA NIH HHS R21 DA047527NIDA NIH HHS R21 DA051921NIDA NIH HHS R33 DA047527NIDA NIH HHS U01 DA041602NIDA NIH HHS U01 DA047638NIDA NIH HHS U01 DA048279NIDA NIH HHS U24 DA039832NIMH NIH HHS DP2 MH122403NIMH NIH HHS MH109532NIMH NIH HHS U01 MH109532
Abstract
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.
Indexed as
cross-speciesdata integrationdrug abusegenomicsGWASmodel organismsmulti-omicsubstance use disordersworking group
Identifiers
What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.