Evidence map›Paper›PMID 33896778›Full record

ArticleSaudi medical journal2021

Glutathione and oxidized nicotinamide adenine dinucleotide (NAD

Feda S Aljaser, Hazem K Ghneim, Mashael M ALshubaily, Manal Abudawood, Faisal Almajed, Sabiha Fatima, Yazeed A ALsheikh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. NADNature metabolism · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Feda S AljaserFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Hazem K GhneimFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Mashael M ALshubailyFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Manal AbudawoodFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Faisal AlmajedFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Sabiha FatimaFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Yazeed A ALsheikhFrom the Department of Clinical Laboratory Sciences and the Chair of Medical and Molecular Genetics Research (Aljaser, Ghneim, Abudawood, Fatima, ALsheikh), College of Applied Medical Sciences, King Saud University; from the Department of Obstetrics and Gynecology (ALshubaily), College of Medicine, King Saud University; from the Department of Clinical Laboratory Sciences (Almajed), College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
King Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the oxidation state and gene expression profiles of relevant enzymes in intrauterine growth restriction (IUGR) patients in Saudi Arabia.

methodsCurrent case-control study involved plasma and placental tissue samples from 25 IUGR patients and 25 healthy pregnant (HP) women attending the Obstetrics and Gynecology Clinic, King Khalid University Hospital, Riyadh, Saudi Arabia, between April and November 2017. We compared hydrogen peroxide, superoxide anions, malondialdehyde, and oxidative stress markers levels and the activities of glutathione-related enzymes (glutathione peroxidase [GPx], glutathione reductase [GR], glutathione S-transferase [GST], glutamate cysteine ligase [GCL], glutathione synthetase [GS], reduced glutathione [GSH], oxidized glutathione [GSSG], and oxidized nicotinamide adenine dinucleotide [NAD

resultsOxidative stress markers significantly differed in IUGR samples, while GSH levels and GPx, GR, GST, GCL, and GS activities and their placental mRNA transcriptional levels were significantly lower. Plasma and placental NAD

conclusionsIntrauterine growth restriction patients show a metabolic shift in favor of oxidation compared to HP women.

Indexed as

GlutathioneNADCase-Control StudiesFemaleFetal Growth RetardationHumansOxidation-ReductionOxidative StressPlacentaPregnancySaudi ArabiaGlutathioneNADenzymes gene expressionintrauterine growth restrictionoxidative stressplacental tissueplasma

Identifiers

PMID33896778
PMCPMC9149688
OpenAlexW3159050107

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.