ArticleCancer biomarkers : section A of Disease markers2021
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
Article in Cancer biomarkers : section A of Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Transcriptomic landscape of oral potentially malignant disorders: a meta-analysis approach.Human cell · 2026Pooled it
- ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role.World journal of clinical oncology · 2025Review
- [Dynamic Succession of Urokinase-Type Plasminogen Activator in an Oral Squamous Cell Carcinoma Model].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Causal role of immune cells in head and neck squamous cell carcinoma.Discover oncology · 2025Article
- Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation.Bioinformation · 2025Article
- Review
- Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review.International journal of molecular sciences · 2024Article
- Salivary diagnostics: opportunities and challenges.Theranostics · 2024Review
- Oral Lichen Planus and Oral Squamous Cell Carcinoma share key oncogenic signatures.Scientific reports · 2022Article
- Advances in the Diagnosis, Monitoring, and Progression of Oral Cancer through Saliva: An Update.BioMed research international · 2022Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundOral squamous cell carcinoma (OSCC) usually originates from oral potentially malignant disorders (OPMD), such as oral leukoplakia (OLK) and oral lichen planus (OLP). Identifying biomarkers for the early diagnosis and evaluation of malignant transformation in OPMD could improve the survival rate of OSCC patients.
objectiveThe present study aimed to screen for potential salivary biomarkers for evaluating the malignant transformation of OPMD.
methodsSalivary proteases from OLK and OSCC patients or healthy donors and proteases in cultural medium from DOK and Cal-27 cells were detected with a human protease array kit. The concentrations of the salivary Kallikrein 5 (KLK5) and urokinase-type plasminogen activator (uPA) proteases were measured by ELISA. Receiver operating characteristics (ROC) to determine the potential value of these proteases in clinical diagnosis were calculated using SPSS software. Immunohistochemistry was used to detect the KLK5 and uPA expression in the oral organizations.
resultsThe salivary protease spectrum was different among patients with OLK and OSCC and healthy donors. KLK5 and uPA levels in saliva tended to increase as the disease progressed (healthy < OPMD [OLK and OLP] < OSCC). ROC curves showed the optimum diagnostic cutoffs for KLK5 as a biomarker for OLK, OLP, and OSCC were 5.97, 6.03, and 9.45 pg/mL, respectively, while the cutoffs for uPA were 17.19, 17.26, and 20.96 pg/mL. Their combined analysis showed a higher sensitivity for the differential diagnosis of disease. Furthermore, higher levels of KLK5 and uPA were observed in OSCC tissues than in OLK and OLP.
conclusionsSalivary KLK5 and uPA are potential biomarkers for evaluating OLK and OLP malignant transformation and early diagnosis of OSCC.
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