Evidence map›Paper›PMID 33898183›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management.

Pooyan Makvandi, Uros Josic, Masoud Delfi, Filippo Pinelli, Vahid Jahed, Emine Kaya, Milad Ashrafizadeh, Atefeh Zarepour, Filippo Rossi, Ali Zarrabi and 6 more

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. [Frontier research on smart delivery biomaterials in the field of oral tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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  14. Nanotherapies Based on ROS Regulation in Oral Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Pooyan MakvandiChemistry Department, Faculty of Science Shahid Chamran University of Ahvaz Ahvaz 6153753843 Iran.ORCID 0000-0003-2456-0961
Uros JosicDepartment of Biomedical and Neuromotor Sciences University of Bologna Via San Vitale 59 Bologna 40125 Italy.
Masoud DelfiDepartment of Chemical Sciences University of Naples "Federico II" Complesso Universitario Monte S. Angelo, Via Cintia Naples 80126 Italy.
Filippo PinelliDepartment of Chemistry, Materials and Chemical Engineering Politecnico di Milano Technical University Milano 20133 Italy.
Vahid JahedBiomedical Engineering Division, Faculty of Chemical Engineering Tarbiat Modares University Tehran Iran.
Emine KayaFaculty of Dentistry Istanbul Okan University Tuzla Campus Tuzla Istanbul 34959 Turkey.
Milad AshrafizadehFaculty of Engineering and Natural Sciences Sabanci University Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı Tuzla Istanbul 34956 Turkey.
Atefeh ZarepourSabanci University Nanotechnology Research and Application Center (SUNUM) Tuzla Istanbul 34956 Turkey.
Filippo RossiDepartment of Chemistry, Materials and Chemical Engineering Politecnico di Milano Technical University Milano 20133 Italy.
Ali ZarrabiSabanci University Nanotechnology Research and Application Center (SUNUM) Tuzla Istanbul 34956 Turkey.
Tarun AgarwalDepartment of Biotechnology Indian Institute of Technology Kharagpur Kharagpur West Bengal 721302 India.
Ehsan Nazarzadeh ZareSchool of Chemistry Damghan University Damghan 36716-41167 Iran.
Matineh GhomiChemistry Department, Faculty of Science Shahid Chamran University of Ahvaz Ahvaz 6153753843 Iran.
Tapas Kumar MaitiDepartment of Biotechnology Indian Institute of Technology Kharagpur Kharagpur West Bengal 721302 India.
Lorenzo BreschiDepartment of Biomedical and Neuromotor Sciences University of Bologna Via San Vitale 59 Bologna 40125 Italy.
Franklin R TayThe Dental College of Georgia Augusta University 1430 John Wesley Gilbert Drive Augusta GA 30192 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

Indexed as

Administration, OralAnti-Infective AgentsDrug Delivery SystemsHumansMouth DiseasesMouth NeoplasmsNanoparticlesTissue EngineeringAnti-Infective Agentsantibacterialantiviraldrug deliveryoral cancertissue regeneration

Identifiers

PMID33898183
PMCPMC8061367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.