Evidence map›Paper›PMID 33898262›Full record

ArticleMolecular genetics and metabolism reports2021

Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model.

Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Nakulan Nanthakumar, Ibrahim T Fazmin, Charlotte E Edling, Christopher L-H Huang, Kamalan Jeevaratnam

Open access · goldAbstract read
In one paragraph

Article in Molecular genetics and metabolism reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Khalil SaadehFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Karan R ChaddaFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Shiraz AhmadFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Haseeb ValliPhysiological Laboratory and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Nakulan NanthakumarFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Ibrahim T FazminFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Charlotte E EdlingFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Christopher L-H HuangFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
Kamalan JeevaratnamFaculty of Health and Medical Sciences, University of Surrey, GU2 7AL Guildford, United Kingdom.
University of Surrey · GBUniversity of Cambridge · GBUniversity of Bristol · GB

Funding

British Heart Foundation PG/14/79/31102Medical Research Council MR/M001288/1
6 · The paper itself

Abstract

Mitochondrial dysfunction underlying metabolic disorders such as obesity and diabetes mellitus is strongly associated with cardiac arrhythmias. Murine Pgc-1α

Indexed as

ArrhythmiasCoactivator-1 transcriptional coactivator (Pgc-1)Conduction velocityIon channelsMitochondriaPeroxisome proliferator activated receptor-γ (PPARγ)Quantitative PCR

Identifiers

PMID33898262
PMCPMC8059080
OpenAlexW3153566964

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.