ArticleBioactive materials2021
Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The trial behind it
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Who cites it
39 citing papers in PubMed, 150 citations in OpenAlex.
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- Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery.Advanced healthcare materials · 2026Review
- Modern Approaches and Emerging Biological Therapies to Treat Fracture Nonunion.Pharmaceutics · 2025Review
- Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy.Materials today. Bio · 2025Article
- Cast-Molded Channelized Hydrogel Scaffolds With Stereolithography-Printed Templates.Biotechnology and bioengineering · 2025Article
- Research Progress of Sodium Alginate-Based Hydrogels in Biomedical Engineering.Gels (Basel, Switzerland) · 2025Review
- Hydroxyproline-Modified Chitosan-Based Hydrogel Dressing Incorporated with Epigallocatechin-3-Gallate Promotes Wound Healing Through Immunomodulation.Gels (Basel, Switzerland) · 2025Article
- Biopolymer Membranes for Osmotic Power Generation in Bionic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications.Advanced healthcare materials · 2025Article
- Unveiling the Potential of Bioactive Glass in Volumetric Muscle Loss Regeneration.Materials (Basel, Switzerland) · 2025Review
- Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration.MedComm · 2025Review
- Porous Hydrogels Prepared by Two-Step Gelation Method for Bone Regeneration.Journal of functional biomaterials · 2025Article
- Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization.Frontiers in immunology · 2025Article
- Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications.Molecular pharmaceutics · 2024Review
- Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation.Polymers · 2024Review
- Development of alginate/chitosan hydrogel loaded with obestatin and evaluation of collagen type I, III, VEGF and TGF-βSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization.Bioactive materials · 2024Article
- Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate, which impedes tissue regeneration. Recently, hydrogels with macropores and/or controlled degradation attract more and more attention for solving this problem. Sodium alginate/Bioglass (SA/BG) hydrogel, which has been reported to be an injectable and bioactive hydrogel, is also limited to be used as tissue engineering scaffolds due to its nanosized pores. Therefore, in this study, degradation of SA/BG hydrogel was modulated by grafting deferoxamine (DFO) to SA. The functionalized grafted DFO-SA (G-DFO-SA) was used to form G-DFO-SA/BG injectable hydrogel. In vitro degradation experiments proved that, compared to SA/BG hydrogel, G-DFO-SA/BG hydrogel had a faster mass loss and structural disintegration. When the hydrogels were implanted subcutaneously, G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG hydrogel. In addition, in a rat full-thickness skin defect model, wound healing studies showed that, G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels formation. Therefore, G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation, which suggesting a promising application potential in tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.