Evidence map›Paper›PMID 33898925›Full record

ReviewSN comprehensive clinical medicine2021

Repositioned Drugs for COVID-19-the Impact on Multiple Organs.

Christina Chan, Sean T Foster, Kayla G Chan, Matthew J Cacace, Shay L Ladd, Caleb T Sandum, Paul T Wright, Brett Volmert, Weiyang Yang, Aitor Aguirre and 2 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in SN comprehensive clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Christina ChanDepartment of Chemical Engineering and Materials Sciences, Michigan State University, 428 S. Shaw Lane, Room 2100 EB, East Lansing, MI 48824 USA.
Sean T Foster *Department of Chemical Engineering and Materials Sciences, Michigan State University, 428 S. Shaw Lane, Room 2100 EB, East Lansing, MI 48824 USA.
Kayla G Chan *Integrative Neuroscience Program, Binghamton University, Binghamton, NY USA.
Matthew J Cacace *Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA USA.
Shay L Ladd *Department of Chemical Engineering and Materials Sciences, Michigan State University, 428 S. Shaw Lane, Room 2100 EB, East Lansing, MI 48824 USA.
Caleb T SandumDepartment of Chemical Engineering and Materials Sciences, Michigan State University, 428 S. Shaw Lane, Room 2100 EB, East Lansing, MI 48824 USA.
Paul T WrightDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA USA.
Brett VolmertDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI USA.
Weiyang YangInstitute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI USA.
Aitor AguirreDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI USA.
Wen LiInstitute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI USA.
Neil T WrightDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI USA.
Michigan State University · USBinghamton University · USPennsylvania State University · USVirginia Tech · US

Funding

An iPSC-Derived NRSF-Dependent Epigenetic Model of Neuropathic PainR21NS116496 · NINDS · MICHIGAN STATE UNIVERSITY · PI CHAN, CHRISTINA · 2020 to 2020
$430k
NINDS NIH HHS R21 NS116496
6 · The paper itself

Abstract

This review summarizes published findings of the beneficial and harmful effects on the heart, lungs, immune system, kidney, liver, and central nervous system of 47 drugs that have been proposed to treat COVID-19. Many of the repurposed drugs were chosen for their benefits to the pulmonary system, as well as immunosuppressive and anti-inflammatory effects. However, these drugs have mixed effects on the heart, liver, kidney, and central nervous system. Drug treatments are critical in the fight against COVID-19, along with vaccines and public health protocols. Drug treatments are particularly needed as variants of the SARS-Cov-2 virus emerge with some mutations that could diminish the efficacy of the vaccines. Patients with comorbidities are more likely to require hospitalization and greater interventions. The combination of treating severe COVID-19 symptoms in the presence of comorbidities underscores the importance of understanding the effects of potential COVID-19 treatments on other organs. Supplementary Information: The online version contains supplementary material available at 10.1007/s42399-021-00874-8.

Indexed as

Central nervous systemCOVID-19Drug repositioningHeartImmune systemKidneysLiverLungs

Identifiers

PMID33898925
PMCPMC8057921
OpenAlexW3153254359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.