Evidence mapPaperPMID 33899493Full record

ReviewAntioxidants & redox signaling2021

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease.

Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J Belin de Chantemèle, David J R Fulton, Tohru Fukai

Open access · greenAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Metabolic Reprogramming of Microglia in Neuroinflammation and Depression.International journal of molecular sciences · 2026
    Review
  4. SC2-3, a Marine Nutrient Glycopeptide fromFoods (Basel, Switzerland) · 2026
    Article
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  9. Article
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  16. Article
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  18. Review
  19. Article
  20. Metabolic Responses to Redox Stress in Vascular Cells.Antioxidants & redox signaling · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Masuko Ushio-FukaiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID 0000-0001-7048-2381
Dipankar AshVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Sheela NagarkotiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Eric J Belin de ChantemèleVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
David J R FultonVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Tohru FukaiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID 0000-0001-9864-571X
Augusta University · US

Funding

Mechanism of cardiovascular disease in premenopausal womenR01HL155265 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2024
$1.6M
Redox Regulation of Cu Importer CTR1 in AngiogenesisR01HL147550 · NHLBI · AUGUSTA UNIVERSITY · PI TOHRU FUKAI, Masuko Ushio-Fukai · 2022 to 2023
$1.5M
Leptin in HIV associated vascular diseasesR01HL147639 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2023
$997k
Cu importer CTR1 Cys189 oxidation in atherosclerosisI01BX001232 · CHARLIE NORWOOD VA MEDICAL CENTER · 2025 to 2025
American Heart Association-American Stroke Association 17POST33660754BLRD VA I01 BX001232NHLBI NIH HHS R01 HL116976NHLBI NIH HHS R01 HL130301NHLBI NIH HHS R01 HL133613NHLBI NIH HHS R01 HL135584NHLBI NIH HHS R01 HL147159NHLBI NIH HHS R01 HL147550NHLBI NIH HHS R01 HL147639NHLBI NIH HHS R01 HL155265NHLBI NIH HHS R01 HL160014
6 · The paper itself

Abstract

Reactive oxygen species (ROS;

Indexed as

Cardiovascular DiseasesHomeostasisHumansMetabolic Networks and PathwaysNADPReactive Nitrogen SpeciesReactive Oxygen SpeciesSignal TransductionNADPReactive Nitrogen SpeciesReactive Oxygen Speciesmetabolismoxidative stressreactive nitrogen speciesreactive oxygen speciesredox signaling

Identifiers

PMID33899493
PMCPMC8418449
OpenAlexW3159729004

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.