Evidence map›Paper›PMID 33900016›Full record

ArticleEMBO reports2021

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression.

Priyanka Jamadagni, Maximilian Breuer, Kathrin Schmeisser, Tatiana Cardinal, Betelhem Kassa, J Alex Parker, Nicolas Pilon, Eric Samarut, Shunmoogum A Patten

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  10. Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.International journal of molecular sciences · 2024
    Review
  11. CHD7 regulates craniofacial cartilage development via controlling HTR2B expression.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  12. Review
  13. Deletion of theInternational journal of molecular sciences · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Craniofacial and cardiac defects inFrontiers in cell and developmental biology · 2022
    Article
  18. Eyes on CHARGE syndrome: Roles of CHD7 in ocular development.Frontiers in cell and developmental biology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Priyanka JamadagniINRS- Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada.
Maximilian BreuerINRS- Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada.
Kathrin SchmeisserCentre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.
Tatiana CardinalCentre d'Excellence en Recherche sur les Maladies Orphelines - Fondation Courtois (CERMO-FC), Université du Québec à Montréal (UQAM), Montréal, QC, Canada.
Betelhem KassaINRS- Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada.
J Alex ParkerCentre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.ORCID 0000-0002-3333-2445
Nicolas PilonCentre d'Excellence en Recherche sur les Maladies Orphelines - Fondation Courtois (CERMO-FC), Université du Québec à Montréal (UQAM), Montréal, QC, Canada.ORCID 0000-0003-3641-0776
Eric SamarutCentre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.
Shunmoogum A PattenINRS- Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada.ORCID 0000-0002-2782-3547
Centre Hospitalier de l’Université de Montréal · CAInstitut National de la Recherche Scientifique · CAUniversité du Québec à Montréal · CA

Funding

Canada Foundation for Innovation (CFI)CHARGE Syndrome FoundationCIHRFonds de Recherche du Québec - Santé (FRQS)Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)Rare Disease Foundation (RDF)
6 · The paper itself

Abstract

Mutations in the chromatin remodeller-coding gene CHD7 cause CHARGE syndrome (CS). CS features include moderate to severe neurological and behavioural problems, clinically characterized by intellectual disability, attention-deficit/hyperactivity disorder and autism spectrum disorder. To investigate the poorly characterized neurobiological role of CHD7, we here generate a zebrafish chd7

Indexed as

Autism Spectrum DisorderAnimalsCaenorhabditis elegansChromatinDNA-Binding ProteinsDNA HelicasesGABAergic NeuronsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMutationZebrafishCHD7 protein, humanChromatinDNA-Binding ProteinsDNA HelicasesIntracellular Signaling Peptides and ProteinsMembrane ProteinsPAQR3 protein, humanbehaviourCHD7GABAneurodevelopmentzebrafish

Identifiers

PMID33900016
PMCPMC8183419
OpenAlexW3158914167

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.