Evidence map›Paper›PMID 33900547›Full record

ArticleNeurotoxicity research2021

Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.

Dalian Ding, Tomas Prolla, Shinichi Someya, Senthilvelan Manohar, Richard Salvi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Roles of Sirtuins in Hearing Protection.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Dalian DingCenter for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA.
Tomas ProllaDepartment of Genetics and Medical Genetics, University of Wisconsin, 702 W Johnson St 1101, Madison, WI, 53715, USA.
Shinichi SomeyaDepartment of Aging and Geriatrics, University of Florida, Gainsville, FL, 32611, USA.
Senthilvelan ManoharCenter for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA.
Richard SalviCenter for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA. salvi@buffalo.edu.ORCID http://orcid.org/0000-0001-9061-8602
University at Buffalo, State University of New York · USBuffalo State University · USUniversity of Florida · USUniversity of Wisconsin–Madison · US

Funding

Hyperacusis and Central GainR01DC014693 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SALVI, RICHARD J · 2016 to 2020
$2.3M
Cochlear Detoxification SystemR01DC014437 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2015 to 2019
$2.2M
The Role of mitochondria in Age-Related Hearing LossR01DC011745 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI PROLLA, TOMAS ALBERTO · 2012 to 2016
$2.1M
Mitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing LossR01DC012552 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2013 to 2017
$1.9M
The Role of Glutathione Reductase in Age-related Hearing LossR03DC011840 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2011 to 2013
$432k
NIDCD NIH HHS R01 DC011745NIDCD NIH HHS R01 DC012552NIDCD NIH HHS R01 DC014437NIDCD NIH HHS R01 DC014693NIDCD NIH HHS R03 DC011840
6 · The paper itself

Abstract

Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak, a pro-apoptotic gene, would reduce paraquat ototoxicity or if deletion of Sirt3, which delays age-related hearing loss under caloric restriction, would increase paraquat ototoxicity. We tested these two hypotheses by treating postnatal day 3 cochlear cultures from Bak

Indexed as

AnimalsAnimals, Newbornbcl-2 Homologous Antagonist-Killer ProteinCells, CulturedCochleaDose-Response Relationship, DrugFemaleHair Cells, Auditory, InnerHair Cells, Auditory, OuterHerbicidesMaleMiceMice, Inbred C57BLMice, KnockoutOrgan Culture TechniquesParaquatBak1 protein, mousebcl-2 Homologous Antagonist-Killer ProteinHerbicidesParaquatSirt3 protein, mouseSirtuin 3Auditory nerveHair cellsOtotoxicityParaquatSuperoxide

Identifiers

PMID33900547
PMCPMC8277768
OpenAlexW3157957768

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.