Evidence map›Paper›PMID 33900579›Full record

ReviewSports medicine (Auckland, N.Z.)2021

Muscle Glycogen Metabolism and High-Intensity Exercise Performance: A Narrative Review.

Jeppe F Vigh-Larsen, Niels Ørtenblad, Lawrence L Spriet, Kristian Overgaard, Magni Mohr

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 8 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 8 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
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  6. Physical Demands during Official Competitions in Elite Handball: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
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  9. Trial
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  14. Review
  15. Article
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  18. Does a low-carbohydrate diet impede endurance sports performance? No.The American journal of clinical nutrition · 2026
    Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Jeppe F Vigh-LarsenExercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Niels ØrtenbladDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Lawrence L SprietDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada.
Kristian OvergaardExercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Magni MohrDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. magnim@setur.fo.
Aarhus University · DKUniversity of Guelph · CAUniversity of Southern Denmark · DKUniversity of the Faroe Islands · FO

Funding

The Danish Ministry of Culture FPK.2016-0054
6 · The paper itself

Abstract

Muscle glycogen is the main substrate during high-intensity exercise and large reductions can occur after relatively short durations. Moreover, muscle glycogen is stored heterogeneously and similarly displays a heterogeneous and fiber-type specific depletion pattern with utilization in both fast- and slow-twitch fibers during high-intensity exercise, with a higher degradation rate in the former. Thus, depletion of individual fast- and slow-twitch fibers has been demonstrated despite muscle glycogen at the whole-muscle level only being moderately lowered. In addition, muscle glycogen is stored in specific subcellular compartments, which have been demonstrated to be important for muscle function and should be considered as well as global muscle glycogen availability. In the present review, we discuss the importance of glycogen metabolism for single and intermittent bouts of high-intensity exercise and outline possible underlying mechanisms for a relationship between muscle glycogen and fatigue during these types of exercise. Traditionally this relationship has been attributed to a decreased ATP resynthesis rate due to inadequate substrate availability at the whole-muscle level, but emerging evidence points to a direct coupling between muscle glycogen and steps in the excitation-contraction coupling including altered muscle excitability and calcium kinetics.

Indexed as

ExerciseGlycogenFatigueHumansMusclesMuscle, SkeletalGlycogen

Identifiers

PMID33900579
OpenAlexW3157691503

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.