Evidence map›Paper›PMID 33901402›Full record

ArticleJournal of medicinal chemistry2021

Development of Novel

Li Wang, Hui Wang, Kun Shen, Hyejin Park, Tao Zhang, Xuedan Wu, Mei Hu, Hong Yuan, Yue Chen, Zhanhong Wu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Review
  4. Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Li WangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Hui WangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Kun ShenDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Hyejin ParkDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Tao ZhangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Xuedan WuBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0000-0001-5875-4233
Mei HuDepartment of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Hong YuanBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Yue ChenDepartment of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Zhanhong WuBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Qiu WangDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-6803-9556
Zibo LiBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0000-0002-1063-0298
University of North Carolina at Chapel Hill · USDuke University · USAffiliated Hospital of Southwest Medical University · CN

Funding

Small Animal Imaging CoreU54CA198999 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2015 to 2019
$11.9M
Novel Catalytic Methods for Efficient Radiolabeling of Un-activated Arene Compounds SupplementR01EB029451 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, NICEWICZ, DAVID A · 2020 to 2023
$2.2M
Development of IDO PET agents for immunotherapyR01CA233904 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, MOSCHOS, STERGIOS · 2019 to 2023
$2.0M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
NCI NIH HHS R01 CA233904NCI NIH HHS U54 CA198999NIBIB NIH HHS R01 EB029451NIH HHS S10 OD023611
6 · The paper itself

Abstract

Tumor hypoxia is a major factor responsible for tumor progression, metastasis, invasion, and treatment resistance, leading to low local tumor control and recurrence after radiotherapy in cancers. Here,

Indexed as

Tumor HypoxiaAnimalsCell Line, TumorFluorine RadioisotopesHumansMiceMice, Inbred C57BLMice, NudeNeoplasmsNitroimidazolesPolyethylene GlycolsPositron-Emission TomographyRadiopharmaceuticalsSulfinic AcidsTransplantation, HeterologousFluorine-18Fluorine RadioisotopesNitroimidazolespimonidazolePolyethylene GlycolsRadiopharmaceuticalsSulfinic Acids

Identifiers

PMID33901402
PMCPMC8552308
OpenAlexW3157233331

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.