ArticleStroke and vascular neurology2021
Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations.
Article in Stroke and vascular neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06072963 (Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow: a Feasibility Study
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Left-lateralized glymphatic dysfunction is associated with MoCA-measured cognitive impairment in cerebral small vessel disease: A DTI-ALPS study.IBRO neuroscience reports · 2026Article
- Epidemiology, Pathophysiology, and Medical Management of Intracranial Atherosclerotic Disease.Journal of neuroendovascular therapy · 2026Review
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Dietary Patterns Associated With Risk of Intracranial Atherosclerosis in Older Adults With Hypertension or Myocardial Infarction.Neurology · 2025Article
- MetS in the prediction of asymptomatic intracranial arterial stenosis: the potential mediating role of hsCRP.Stroke and vascular neurology · 2025Article
- Linking metabolic syndrome, cerebral small vessel disease, and cognitive health: insights from a subclinical population study using TriNetX.GeroScience · 2025Article
- Review
- Comparison of SES method and SARIMA model in predicting the number of admissions in the department of neurology.Scientific reports · 2025Article
- Correlation between Neuroimaging Scores and Carotid Artery Ultrasound Features in Cerebral Small Vessel Disease Patients.Cerebrovascular diseases extra · 2025Article
- White matter microstructural damage and its effect on cognitive impairment in patients with metabolic syndrome and cerebral small vessel disease.Frontiers in neurology · 2025Article
- Development and validation of a web-based dynamic nomogram to predict individualized risk of severe carotid artery stenosis based on digital subtract angiography.Frontiers in neurology · 2025Article
- Risk factor differences in five-year progression of Intracranial artery stenosis and cerebral small vessel disease in general population.BMC neurology · 2024Article
- Article
- Association between BMI-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study.International journal of obesity (2005) · 2024Article
- Brain frailty associated with stroke events in anterior circulation large artery occlusion.BMC neurology · 2024Article
- In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes.Stroke and vascular neurology · 2024Article
- Evaluation of peripapillary retinal nerve fiber layer thickness in intracranial atherosclerotic stenosis.BMC ophthalmology · 2023Article
- The 2023 Taiwan Stroke Society Guidelines for the management of patients with intracranial atherosclerotic disease.Journal of the Chinese Medical Association : JCMA · 2023Article
- Asymmetry of Lacunae between Brain Hemispheres Is Associated with Atherosclerotic Occlusions of Middle Cerebral Artery.Brain sciences · 2023Article
- Role of cerebral microbleeds in acute ischemic stroke and atrial fibrillation.Journal of thrombosis and thrombolysis · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThis study aimed to investigate the association of metabolic syndrome (MetS) with both intracranial atherosclerotic stenosis (ICAS) and imaging markers of cerebral small vessel disease (CSVD) in a community-based sample.
methodsThis study included 943 participants (aged 55.6±9.2 years, 36.1% male) from the community-based Shunyi cohort study. MetS was defined according to the joint interim criteria and quantified by the MetS severity Z-score. ICAS was evaluated by brain magnetic resonance angiography. The MRI markers of CSVD, including white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS), were assessed. Multiple regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD markers.
resultsWe found that risk of ICAS (OR=1.75, 95% CI 1.39 to 2.21, p<0.001) increased consistently with MetS severity. MetS severity was significantly associated with higher risks of WMH volume (β=0.11, 95% CI 0.01 to 0.20, p=0.02) and lacunes (OR=1.28, 95% CI 1.03 to 1.59, p=0.03) but not the presence of CMBs (OR=0.93, 95% CI 0.74 to 1.16, p=0.51) and PVS severity (EPVS in basal ganglia: OR=0.96, 95% CI 0.84 to 1.09, p=0.51 and EPVS in white matter: OR=1.09, 95% CI 0.96 to 1.23, p=0.21).
conclusionsOur findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery, whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.