Evidence map›Paper›PMID 33904408›Full record

ArticleeLife2021

Quantitative analyses reveal extracellular dynamics of Wnt ligands in

Yusuke Mii, Kenichi Nakazato, Chan-Gi Pack, Takafumi Ikeda, Yasushi Sako, Atsushi Mochizuki, Masanori Taira, Shinji Takada

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  8. Review
  9. Locally fast, globally slow.Biophysical journal · 2025
    Article
  10. Review
  11. Understanding and manipulating extracellular behaviors of Wnt ligands.In vitro cellular & developmental biology. Animal · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. The Emerging Mechanisms of Wnt Secretion and Signaling in Development.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Yusuke MiiNational Institute for Basic Biology and Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan.ORCID 0000-0002-1907-5665
Kenichi NakazatoTheoretical Biology Laboratory, RIKEN, Wako, Japan.
Chan-Gi PackCellular Informatics Laboratory, RIKEN, Wako, Japan.ORCID 0000-0002-6578-3099
Takafumi IkedaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Yasushi SakoCellular Informatics Laboratory, RIKEN, Wako, Japan.
Atsushi MochizukiTheoretical Biology Laboratory, RIKEN, Wako, Japan.
Masanori TairaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Shinji TakadaNational Institute for Basic Biology and Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan.ORCID 0000-0003-4125-6056
National Institute for Basic Biology · JPThe University of Tokyo · JPKyoto University · JPRIKEN · JPRIKEN Advanced Science Institute · JPUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism of intercellular transport of Wnt ligands is still a matter of debate. To better understand this issue, we examined the distribution and dynamics of Wnt8 in

Indexed as

AnimalsDiffusionEmbryo, NonmammalianExtracellular SpaceFrizzled-Related ProteinsIntracellular Signaling Peptides and ProteinsLigandsMembrane ProteinsSpectrometry, FluorescenceWnt ProteinsXenopus laevisFrizzled-Related ProteinsIntracellular Signaling Peptides and ProteinsLigandsMembrane ProteinsWnt Proteinsdevelopmental biologydiffusionFCSFDAPFRAPmorphogenphysics of living systemsWntxenopus

Identifiers

PMID33904408
PMCPMC8139832
OpenAlexW3158326523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.