Evidence map›Paper›PMID 33905762›Full record

ReviewToxicology2021

Nutrition, one-carbon metabolism and arsenic methylation.

Ahlam Abuawad, Anne K Bozack, Roheeni Saxena, Mary V Gamble

Open access · greenAbstract readReview
In one paragraph

Review in Toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Integration of epigenetics into ecotoxicology: insights and fundamental research needs.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  8. Article
  9. Arsenome, Arsenobolome, and Arsenobiolome.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ahlam AbuawadDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Anne K BozackDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Roheeni SaxenaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Mary V GambleDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: mvg7@cumc.columbia.edu.
Columbia University · USCenter for Environmental Health · USColumbia University Irving Medical Center · US

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
IMSD at Columbia's Mailman School of Public HealthR25GM062454 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDSMITH, JEFF, MARTINS, SILVIA SABOIA · 2002 to 2019
$7.3M
Interdisciplinary approaches for understanding the metabolic effects of arsenic and manganeseR01ES030945 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2020 to 2022
$1.9M
Arsenic Methylation, One-Carbon Metabolism, and Diabetes IncidenceF31ES032321 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ABUAWAD, AHLAM KIFAH · 2020 to 2021
$65k
NIEHS NIH HHS F31 ES032321NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P42 ES010349NIEHS NIH HHS R01 ES030945NIGMS NIH HHS R25 GM062454
6 · The paper itself

Abstract

Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAs

Indexed as

AnimalsArsenicCarbonDrinking WaterEnvironmental ExposureFemaleFolic AcidFolic Acid DeficiencyFoodHumansMethylationNutritional StatusObservational Studies as TopicPregnancyPrenatal Exposure Delayed EffectsArsenicCarbonDrinking WaterFolic AcidArsenicArsenic methylationFolateNutritionOne-carbon metabolism

Identifiers

PMID33905762
PMCPMC8349595
OpenAlexW3157890001

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.