Evidence map›Paper›PMID 33906697›Full record

ArticleHereditas2021

Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations.

Yan-Hong Li, Jun-Yi Luo, Bin-Bin Fang, Guo-Li Du, Ting Tian, Fen Liu, Xiao-Mei Li, Yi-Ning Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan-Hong Li *Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Jun-Yi Luo *Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Bin-Bin FangDepartment of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Guo-Li DuDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Ting TianDepartment of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Fen LiuDepartment of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Xiao-Mei LiDepartment of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China. lixm505@163.com.
Yi-Ning YangDepartment of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China. yangyn5126@163.com.
First Affiliated Hospital of Xinjiang Medical University · CNXinjiang Medical University · CN

Funding

13th Five-Year Plan of Xinjiang key discipline 33-0104006020801#Natural Science Foundation of China 81770363Natural Science Foundation of China 81800320Natural Science Foundation of Xinjiang 2020D01C259
6 · The paper itself

Abstract

backgroundCCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the association between CCN1 polymorphisms and ACS among Han and Uygur populations in Xinjiang, China.

resultsIn this case-control study, 1234 Han (547 ACS patients and 687 controls) and 932 Uygur (471 ACS patients and 461 controls) were genotyped using SNPscan

conclusionsOur study document that the CCN1 gene rs6576776 C allele is associated with higher susceptibility of ACS and that the frequencies of GGC and AGC haplotypes are higher among the Uygur ACS patients.

Indexed as

Acute Coronary SyndromeAdultAgedAsian PeopleCase-Control StudiesChinaCysteine-Rich Protein 61EthnicityFemaleGene FrequencyGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedCCN1 protein, humanCysteine-Rich Protein 61Acute coronary syndromeCCN1GenotypingHaplotypePolymorphism

Identifiers

PMID33906697
PMCPMC8080382
OpenAlexW3158640954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.