ArticleNeuropsychiatric disease and treatment2021
Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association of nonpharmacological interventions for cognitive function in older adults with mild cognitive impairment: a systematic review and network meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Trial
- Association between Traditional Chinese Medicine constitution and geriatric functional impairment evaluated by the integrated care for older people approach in the elderly.Journal of traditional and complementary medicine · 2026Article
- Health-related quality of life in Chinese kidney transplant recipients assessed by Chinese medicine quality of life-11 dimensions (CQ-11D).Health and quality of life outcomes · 2026Article
- A Machine Learning and Traditional Chinese Medicine Constitution-Based Prediction Model for Mild Cognitive Impairment in Community-Dwelling Older Adults.Neuropsychiatric disease and treatment · 2026Article
- Effect of -deficiency constitution on cognitive impairment in cerebral small vessel disease and its neuroimaging mechanism.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Exploration of influential factors about deficiency constitution of Traditional Chinese Medicine based on multi-methods.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Article
- Traditional Chinese Medicine Constitution and Cognitive Frailty in Older Adults: Prediction Models and Sleep-Quality Mediation Pathway from a Multicenter Study in China.Clinical interventions in aging · 2025Article
- Yang-deficiency constitution drives poor outcomes in clear cell renal cell carcinoma by modulating the tumour immune microenvironment.Frontiers in immunology · 2025Article
- The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle-aged and older adults with sarcopenia.Aging medicine (Milton (N.S.W)) · 2024Article
- The Effects of Traditional Chinese Herbal Dietary Formula on the Ability of Daily Life and Physical Function in Elderly Patients with Mild Cognitive Impairment.Brain sciences · 2024Article
- Traditional Chinese medicine constitution and sarcopenia: a cross-sectional study.Frontiers in public health · 2024Article
- Development and validation of non-invasive prediction models for migraine in Chinese adults.The journal of headache and pain · 2023Article
- Effects of Chinese medicine for COVID-19 rehabilitation: a multicenter observational study.Chinese medicine · 2022Article
- Exploration on the Improvement of Cognitive Function and Inflammatory Response in Perimenopausal Patients with Mild Cognitive Impairment by Self-Prepared Ningshen Prescription.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Analysis of Sleep Quality and TCM Constitution Characteristics in 258 Outpatients: A Cross-Sectional Study Based on Outpatient Cases.Applied bionics and biomechanics · 2022Article
- Acupressure and Cognitive Training Can Improve Cognitive Functions of Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in psychology · 2021Article
- Herbal Medicine for Patients with Cognitive Impairment: An Observational Study.Neuropsychiatric disease and treatment · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe incidence of Alzheimer's disease is on the rise, early detection of cognitive impairment of the elderly is very important. In traditional Chinese medicine, constitution is related to the susceptibility of the human body to diseases. Based on the theory of constitution of traditional Chinese medicine (TCM), the human population can be classified into 9 constitutions. However, little is known about the characteristics of medical constitution and related biomarkers in subjects with mild cognitive impairment (MCI).
methodsWe measured the TCM Constitution of 214 subjects by using the Constitution in Chinese Medicine Questionnaire (CCMQ). MMSE and MoCA were used to assess cognitive function. The subjects were divided into mild cognitive impairment group (MCI, n = 152) and normal control group (NC, n = 62). The levels of serum Hcy and serum/urine 8-iso-PGF 2α were determined.
results1) It was found that there was a significant difference in constitution types between MCI and NC. There were significant differences in MMSE and MoCA score, serum Hcy and serum/urine 8-iso-PGF 2a levels between the two groups. 2) In logistic regression analysis, the variables with statistical significance were TCM Constitution of Yang-Deficient, Phlegm-Dampness, Blood-Stasis and abnormal increase of Hcy (OR>1). 3) The MoCA scores had a positive correlation with the MMSE. A statistically significant inverse association was found between serum Hcy, blood and urine 8-iso-PGF 2a and scores of cognitive assessment in MCI.
conclusionConstitution types (Yang-Deficient, Phlegm-Dampness and Blood-Stasis) and abnormal serum Hcy elevation can be used as risk factors for MCI. MoCA scores can serve to detect MCI at early stage. Serum/urine 8-iso-PGF 2α has a certain relationship with MCI. Higher levels of serum/urine 8-iso-PGF 2α are more likely to be associated with MCI risk.
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