Evidence map›Paper›PMID 33907848›Full record

ArticleMolecular medicine reports2021

Oleic acid induces A7r5 cell proliferation and migration associated with increased expression of HGF and p‑p38.

Jingjing Li, Ting Chu, Maosheng Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. American journal of translational research · 2025
    Article
  2. ATP purinergic receptor signalling promotes Sca-1Cell communication and signaling : CCS · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jingjing Li *Department of Clinical Medicine, Jishou University School of Medicine, Jishou, Hunan 416000, P.R. China.
Ting Chu *Department of Nursing, Jishou University School of Medicine, Jishou, Hunan 416000, P.R. China.
Maosheng YangLaboratory of Disorders Genes and Department of Pharmacology, Jishou University School of Pharmacy, Jishou, Hunan 416000, P.R. China.
Jishou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phenotypes and mechanisms underlying the proliferation and migration of vascular smooth muscle cells (VSMCs) induced by oleic acid (OA) are not completely understood. Therefore, the aim of the present study was to further elucidate the effects of OA on the proliferation and migration of VSMCs. Using A7r5 cells, the hepatocyte growth factor (HGF) inhibitor PHA665752 and the p38 MAPK inhibitor SB203580 were utilized, and Cell Counting Kit‑8 (CCK‑8) assays, Transwell assays, flow cytometry, ELISAs, western blotting and reverse transcription‑quantitative PCR (RT‑qPCR) were conducted to assess the effects of OA. CCK‑8 assays indicated that OA promoted (at 5 and 50

Indexed as

AnimalsCell LineCell MovementCell ProliferationHepatocyte Growth FactorHumansImidazolesIndolesMyocytes, Smooth MuscleOleic Acidp38 Mitogen-Activated Protein KinasesPhosphorylationPyridinesSignal TransductionSulfones5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-oneHepatocyte Growth FactorHGF protein, humanImidazolesIndolesOleic Acidp38 Mitogen-Activated Protein KinasesPyridinesSB 203580SulfonesHGFmigrationOAp‑p38proliferationVSMCs

Identifiers

PMID33907848
PMCPMC8127074
OpenAlexW3159108275

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.