Evidence map›Paper›PMID 33909031›Full record

ReviewInvestigative ophthalmology & visual science2021

IMI 2021 Yearly Digest.

Monica Jong, Jost B Jonas, James S Wolffsohn, David A Berntsen, Pauline Cho, Danielle Clarkson-Townsend, Daniel I Flitcroft, Kate L Gifford, Annechien E G Haarman, Machelle T Pardue and 15 more

Open access · goldAbstract readReview
In one paragraph

Review in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Trial
  5. Trial
  6. Mesopic Illumination in Natural Environments: Implications for Myopia Research.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  7. Review
  8. IMI-Myopia Genetics Report.Investigative ophthalmology & visual science · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Access to Myopia Care in the United States-A Narrative Review.Investigative ophthalmology & visual science · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 9 countries.

Monica JongDiscipline of Optometry and Vision Science, University of Canberra, Canberra, Australian Capital Territory, Australia.
Jost B JonasDepartment of Ophthalmology Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
James S WolffsohnOptometry and Vision Science Research Group, Aston University, Birmingham, United Kingdom.
David A BerntsenThe Ocular Surface Institute, College of Optometry, University of Houston, Houston, Texas, United States.
Pauline ChoCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Danielle Clarkson-TownsendCenter for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Decatur, Georgia, United States.
Daniel I FlitcroftDepartment of Ophthalmology, Children's University Hospital, Dublin, Ireland.
Kate L GiffordMyopia Profile Pty Ltd, Brisbane, Queensland, Australia.
Annechien E G HaarmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Machelle T PardueCenter for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Decatur, Georgia, United States.
Kathryn RichdaleCollege of Optometry, University of Houston, Houston, Texas, United States.
Padmaja SankaridurgBrien Holden Vision Institute, Sydney, New South Wales, Australia.
Milly S TedjaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Christine F WildsoetSchool of Optometry, University of California, Berkeley, California, United States.
Joan E Bailey-WilsonComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States.
Jeremy A GuggenheimSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom.
Christopher J HammondSection of Academic Ophthalmology, School of Life Course Sciences, King's College London, London, United Kingdom.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Stuart MacGregorStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
David A MackeyCentre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Anthony M MusolfComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States.
Caroline C W KlaverDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Virginie J M VerhoevenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Earl L SmithCollege of Optometry, University of Houston, Houston, Texas, United States.
Erasmus MC · NLUniversity of Houston · USAtlanta VA Health Care System · USAston University · GBBrien Holden Vision Institute · AUCardiff University · GBHeidelberg University · DEHong Kong Polytechnic University · HKKing's College London · GBNational Human Genome Research Institute · USNational Institutes of Health · USQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AURadboud University Medical Center · NLTemple Street Children's University Hospital · IEUniversity of California, Berkeley · USUniversity of Edinburgh · GBUniversity of Helsinki · FIUniversity of Melbourne · AUUNSW Sydney · AU

Funding

Optically Induced AnisometropiasR01EY003611 · NEI · UNIVERSITY OF HOUSTON · PI Lisa A Ostrin · 1985 to 2026
$11.1M
Genetic Epidemiology of Complex TraitsZIAHG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$10.5M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
Retinal Mechanisms of Refractive DevelopmentR01EY016435 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Machelle T. Pardue · 2009 to 2026
$5.4M
Investigating the Impacts of in utero Circadian Disruption on Epigenetic Regulation of Metabolism and DiabetesF31HD097918 · NICHD · EMORY UNIVERSITY · PI WALLACE, DANIELLE A. · 2018 to 2020
$126k
Medical Research Council MC_UU_00007/10NEI NIH HHS R01 EY003611NEI NIH HHS R01 EY016435NICHD NIH HHS F31 HD097918NIEHS NIH HHS T32 ES012870RRD VA IK6 RX003134
6 · The paper itself

Abstract

Purpose: The International Myopia Institute (IMI) Yearly Digest highlights new research considered to be of importance since the publication of the first series of IMI white papers. Methods: A literature search was conducted for articles on myopia between 2019 and mid-2020 to inform definitions and classifications, experimental models, genetics, interventions, clinical trials, and clinical management. Conference abstracts from key meetings in the same period were also considered. Results: One thousand articles on myopia have been published between 2019 and mid-2020. Key advances include the use of the definition of premyopia in studies currently under way to test interventions in myopia, new definitions in the field of pathologic myopia, the role of new pharmacologic treatments in experimental models such as intraocular pressure-lowering latanoprost, a large meta-analysis of refractive error identifying 336 new genetic loci, new clinical interventions such as the defocus incorporated multisegment spectacles and combination therapy with low-dose atropine and orthokeratology (OK), normative standards in refractive error, the ethical dilemma of a placebo control group when myopia control treatments are established, reporting the physical metric of myopia reduction versus a percentage reduction, comparison of the risk of pediatric OK wear with risk of vision impairment in myopia, the justification of preventing myopic and axial length increase versus quality of life, and future vision loss. Conclusions: Large amounts of research in myopia have been published since the IMI 2019 white papers were released. The yearly digest serves to highlight the latest research and advances in myopia.

Indexed as

Quality of LifeDisease ProgressionHumansMyopiaOrthokeratologic ProceduresRefraction, Ocular

Identifiers

PMID33909031
PMCPMC8088231
OpenAlexW3157126752

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.