Evidence map›Paper›PMID 33910427›Full record

ArticleDrug metabolism reviews2021

Novel advances in biotransformation and bioactivation research - 2020 year in review.

S Cyrus Khojasteh, Upendra A Argikar, James P Driscoll, Carley J S Heck, Lloyd King, Klarissa D Jackson, Wenying Jian, Amit S Kalgutkar, Grover P Miller, Valerie Kramlinger and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

S Cyrus KhojastehDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.ORCID 0000-0002-8385-9288
Upendra A ArgikarTranslational Medicine, Novartis Institutes for Biomedical Research, Inc., Cambridge, MA, USA.ORCID 0000-0002-0939-0813
James P DriscollDepartment of Drug Metabolism and Pharmacokinetics, MyoKardia, Inc., South San Francisco, CA, USA.ORCID 0000-0002-3736-1673
Carley J S HeckMedicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USA.ORCID 0000-0002-6842-3670
Lloyd KingDepartment of DMPK, UCB Biopharma, Slough, UK.ORCID 0000-0002-3301-7533
Klarissa D JacksonDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.ORCID 0000-0002-9388-9800
Wenying JianDrug Metabolism and Pharmacokinetics, Janssen Research & Development, Spring House, PA, USA.ORCID 0000-0002-8731-981X
Amit S KalgutkarMedicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.ORCID 0000-0001-9701-756X
Grover P MillerDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-4743-8187
Valerie KramlingerTranslational Medicine, Novartis Institutes for Biomedical Research, Inc., Cambridge, MA, USA.ORCID 0000-0002-7237-164X
Ivonne M C M RietjensDivision of Toxicology, Wageningen University, Wageningen, The Netherlands.ORCID 0000-0003-1894-3544
Aaron M TeitelbaumDrug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.ORCID 0000-0001-6737-0928
Kai WangDrug Metabolism and Pharmacokinetics, Janssen Research & Development, San Diego, CA, USA.ORCID 0000-0002-9457-7534
Cong WeiDrug Metabolism & Pharmacokinetics, Biogen Inc., Cambridge, MA, USA.

Funding

Photochemical synthesis of bioactive moleculesR01GM127774 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEPHENSON, COREY · 2018 to 2021
$1.9M
Systematic Discovery of Bioactivation-Associated Structural AlertsR01GM140635 · NIGMS · WASHINGTON UNIVERSITY · PI MILLER, GROVER P, SWAMIDASS, SANJAY JOSHUA · 2020 to 2023
$1.5M
DATA AND TOOLS FOR MODELING METABOLISM AND REACTIVITYR01LM012222 · NLM · WASHINGTON UNIVERSITY · PI MILLER, GROVER P, SWAMIDASS, SANJAY JOSHUA · 2016 to 2019
$1.5M
Computationally modeling the impact of ontogeny on drug metabolic fateR01LM012482 · NLM · UNIV OF ARKANSAS FOR MED SCIS · PI MILLER, GROVER P, SWAMIDASS, SANJAY JOSHUA · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM127774NIGMS NIH HHS R01 GM140635NLM NIH HHS R01 LM012222NLM NIH HHS R01 LM012482
6 · The paper itself

Abstract

This annual review is the sixth of its kind since 2016 (see references). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation and bioactivation. These fields are constantly evolving with new molecular structures and discoveries of corresponding pathways for metabolism that impact relevant drug development with respect to efficacy and safety. Based on the selected articles, we created three sections: (1) drug design, (2) metabolites and drug metabolizing enzymes, and (3) bioactivation and safety (Table 1). Unlike in years past, more biotransformation experts have joined and contributed to this effort while striving to maintain a balance of authors from academic and industry settings.[Table: see text].

Indexed as

BiotransformationHumansbioactivationbiotransformationDrug metabolismnonp450 enzymesp450 enzymes

Identifiers

PMID33910427
PMCPMC8826528

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.