Evidence map›Paper›PMID 33911098›Full record

ArticleScientific reports2021

Stress-induced differential gene expression in cardiac tissue.

Ana Elisa T S de Carvalho, Marco A Cordeiro, Luana S Rodrigues, Daniela Ortolani, Regina C Spadari

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. MicroRNAs' Impact on Heart Diseases.International journal of molecular sciences · 2025
    Review
  4. Article
  5. An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana Elisa T S de CarvalhoLaboratory of Stress Biology, Department of Biosciences, Institute of Health and Society, Campus Baixada Santista, Federal University of São Paulo (UNIFESP), Rua Silva Jardim,136, sala 310, Santos, São Paulo, 11020-015, Brazil. aetscarvalho@unifesp.br.
Marco A CordeiroLaboratory of Stress Biology, Department of Biosciences, Institute of Health and Society, Campus Baixada Santista, Federal University of São Paulo (UNIFESP), Rua Silva Jardim,136, sala 310, Santos, São Paulo, 11020-015, Brazil.
Luana S RodriguesLaboratory of Stress Biology, Department of Biosciences, Institute of Health and Society, Campus Baixada Santista, Federal University of São Paulo (UNIFESP), Rua Silva Jardim,136, sala 310, Santos, São Paulo, 11020-015, Brazil.
Daniela OrtolaniLaboratory of Stress Biology, Department of Biosciences, Institute of Health and Society, Campus Baixada Santista, Federal University of São Paulo (UNIFESP), Rua Silva Jardim,136, sala 310, Santos, São Paulo, 11020-015, Brazil.
Regina C SpadariLaboratory of Stress Biology, Department of Biosciences, Institute of Health and Society, Campus Baixada Santista, Federal University of São Paulo (UNIFESP), Rua Silva Jardim,136, sala 310, Santos, São Paulo, 11020-015, Brazil. regina.spadari@unifesp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (β-AR) in the heart. Whether and how stress affects the expression of components of the intracellular environment in the heart is still, however, unknown. This paper used microarray to analyze the gene expression in the left ventricle wall of rats submitted to foot shock stress, treated or not treated with the selective β

Indexed as

Stress, PhysiologicalAdrenergic beta-2 Receptor AntagonistsAnimalsCorticosteroneDown-RegulationHeart VentriclesImmune SystemMaleMyocardiumRatsRats, WistarReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Receptors, GlucocorticoidUp-RegulationAdrenergic beta-2 Receptor AntagonistsCorticosteroneReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Receptors, Glucocorticoid

Identifiers

PMID33911098
PMCPMC8080723

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.