Evidence map›Paper›PMID 33911856›Full record

ArticleClinical interventions in aging2021

Dynamic Changes in Liver Function Tests and Their Correlation with Illness Severity and Mortality in Patients with COVID-19: A Retrospective Cohort Study.

Wei Xu, Chenlu Huang, Ling Fei, Qiang Li, Liang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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  10. Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19).Medical science monitor : international medical journal of experimental and clinical research · 2022
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei Xu *Department of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People's Republic of China.
Chenlu Huang *Department of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People's Republic of China.ORCID 0000-0003-1752-1614
Ling Fei *Department of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People's Republic of China.
Qiang LiDepartment of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People's Republic of China.
Liang ChenDepartment of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People's Republic of China.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the longitudinal changes in liver function tests, and their association with illness severity and mortality in patients with COVID-19.

methodsA retrospective cohort study of 1003 hospitalized patients with COVID-19 was conducted. Longitudinal liver function tests and clinical outcomes were analyzed.

resultsAbnormal liver function parameters were observed, both at admission (ALT 13.2%, AST 8.5%, ALP 2.0%, GGT 7.4%, LDH 37.6%, TBIL 4.0%, DBIL 7.8%, Albumin 10.1%) and peak hospitalization (ALT 29.4%, AST 17.5%, ALP 2.6%, GGT 13.4%, LDH 49.4%, TBIL 10.1%, DBIL 18.0%, Albumin 30.6%) in patients with COVID-19. Compared with non-severe patients, severe patients had markedly higher liver function parameters from baseline to 30 days after hospital admission. Abnormal ALT and LDH at hospital admission and some medications use (Hydroxychloroquine, Lopinavir/Ritonavir, and Traditional Chinese medicines) were associated with peak hospitalization ALT > 5× the upper limit unit of normal (ULN). On multivariate analysis, age >60 years, male, obesity, comorbidity, abnormal LDH and albumin at hospital admission and peak hospitalization were associated with progression to severe COVID-19 (OR > 1;

conclusionDynamic abnormalities of liver function parameters are common in hospitalized patients with COVID-19, and associated with illness severity and mortality.

Indexed as

AdultAgedAge FactorsComorbidityCOVID-19FemaleHospitalizationHumansLiver Function TestsMaleMiddle AgedRetrospective StudiesSARS-CoV-2Severity of Illness IndexSex Factorsclinical outcomesCOVID-19liver function parametersliver injurySARS-CoV-2

Identifiers

PMID33911856
PMCPMC8071705
OpenAlexW3154461102

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.