Evidence map›Paper›PMID 33912816›Full record

ArticleiScience2021

Immune activation during

Albert M Isaacs, Sarah U Morton, Mercedeh Movassagh, Qiang Zhang, Christine Hehnly, Lijun Zhang, Diego M Morales, Shamim A Sinnar, Jessica E Ericson, Edith Mbabazi-Kabachelor and 10 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Albert M IsaacsDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sarah U MortonDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Mercedeh MovassaghDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Qiang ZhangDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Christine HehnlyInstitute for Personalized Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
Lijun ZhangInstitute for Personalized Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
Diego M MoralesDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shamim A SinnarCenter for Neural Engineering, Pennsylvania State University, State College, PA 16801, USA.
Jessica E EricsonDepartment of Pediatrics, Pennsylvania State College of Medicine, Hershey, PA 17033, USA.
Edith Mbabazi-KabachelorCURE Children's Hospital of Uganda, Mbale, Uganda.
Peter SsenyongaCURE Children's Hospital of Uganda, Mbale, Uganda.
Justin OnenCURE Children's Hospital of Uganda, Mbale, Uganda.
Ronnie MulondoCURE Children's Hospital of Uganda, Mbale, Uganda.
Mady HornigDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Benjamin C WarfDepartment of Neurosurgery, Harvard Medical School, Boston, MA 02115, USA.
James R BroachInstitute for Personalized Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
R Reid TownsendDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
David D LimbrickDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joseph N PaulsonDepartment of Biostatistics, Product Development, Genentech Inc., South San Francisco, CA 94080, USA.
Steven J SchiffCenter for Neural Engineering, Pennsylvania State University, State College, PA 16801, USA.
Pennsylvania State University · USCURE Children’s Hospital of Uganda · UGWashington University in St. Louis · USHarvard University · USBoston Children's Hospital · USColumbia University · USPenn State Milton S. Hershey Medical Center · USUniversity of Calgary · CA

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Control of the Neonatal Septisome and Hydrocephalus in sub-Saharan AfricaDP1HD086071 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCHIFF, STEVEN J · 2015 to 2019
$4.1M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
NCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842NICHD NIH HHS DP1 HD086071NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

Inflammation during neonatal brain infections leads to significant secondary sequelae such as hydrocephalus, which often follows neonatal sepsis in the developing world. In 100 African hydrocephalic infants we identified the biological pathways that account for this response. The dominant bacterial pathogen was a

Indexed as

ImmunologyProteomicsTranscriptomics

Identifiers

PMID33912816
PMCPMC8065213
OpenAlexW3137688196

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.