ArticleInternational journal of molecular sciences2021
Chronic Low Dose Neutron Exposure Results in Altered Neurotransmission Properties of the Hippocampus-Prefrontal Cortex Axis in Both Mice and Rats.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition.International journal of molecular sciences · 2026Review
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation.Brain structure & function · 2025Article
- Using FASS-LTP in postmortem mice brain tissues to assess pathological synaptic function.Journal of neuroscience methods · 2024Article
- Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation.Research square · 2024Article
- New Radiobiological Principles for the CNS Arising from Space Radiation Research.Life (Basel, Switzerland) · 2023Article
- Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration.International journal of molecular sciences · 2023Article
- Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function.Neural regeneration research · 2022Article
- Editorial to the Special Issue: "Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment".International journal of molecular sciences · 2022Article
- Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.Frontiers in physiology · 2022Article
- Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function.International journal of molecular sciences · 2021Article
- Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System.International journal of molecular sciences · 2021Article
- Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure toFrontiers in behavioral neuroscience · 2021Article
- Effects of Low Dose Neutron-Gamma Field on Cell Cycle and Damage of Human Lymphocytes.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
The proposed deep space exploration to the moon and later to Mars will result in astronauts receiving significant chronic exposures to space radiation (SR). SR exposure results in multiple neurocognitive impairments. Recently, our cross-species (mouse/rat) studies reported impaired associative memory formation in both species following a chronic 6-month low dose exposure to a mixed field of neutrons (1 mGy/day for a total dose pf 18 cGy). In the present study, we report neutron exposure induced synaptic plasticity in the medial prefrontal cortex, accompanied by microglial activation and significant synaptic loss in the hippocampus. In a parallel study, neutron exposure was also found to alter fluorescence assisted single synaptosome LTP (FASS-LTP) in the hippocampus of rats, that may be related to a reduced ability to insert AMPAR into the post-synaptic membrane, which may arise from increased phosphorylation of the serine 845 residue of the GluA1 subunit. Thus, we demonstrate for the first time, that low dose chronic neutron irradiation impacts homeostatic synaptic plasticity in the hippocampal-cortical circuit in two rodent species, and that the ability to successfully encode associative recognition memory is a dynamic, multicircuit process, possibly involving compensatory changes in AMPAR density on the synaptic surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.