Evidence mapPaperPMID 33916487Full record

ReviewLife (Basel, Switzerland)2021

Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation.

Carlo Maria Barbagallo, Angelo Baldassare Cefalù, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Lipid Biochemistry and its Role in Human Diseases.Current medicinal chemistry · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor.Therapeutic advances in endocrinology and metabolism · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo Maria BarbagalloDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.ORCID 0000-0002-4114-038X
Angelo Baldassare CefalùDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.
Antonina GiammancoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.
Davide NotoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.
Rosalia CaldarellaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.
Marcello CiaccioDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-6120-9041
Maurizio Rocco AvernaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.ORCID 0000-0003-3558-9209
Emilio NardiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.ORCID 0000-0003-1844-0285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is one of the most important risk factors for cardiovascular disease (CVD). Despite the kidney having no direct implications for lipoproteins metabolism, advanced CKD dyslipidemia is usually present in patients with CKD, and the frequent lipid and lipoprotein alterations occurring in these patients play a role of primary importance in the development of CVD. Although hypertriglyceridemia is the main disorder, a number of lipoprotein abnormalities occur in these patients. Different enzymes pathways and proteins involved in lipoprotein metabolism are impaired in CKD. In addition, treatment of uremia may modify the expression of lipoprotein pattern as well as determine acute changes. In renal transplantation recipients, the main lipid alteration is hypercholesterolemia, while hypertriglyceridemia is less pronounced. In this review we have analyzed lipid and lipoprotein disturbances in CKD and also their relationship with progression of renal disease. Hypolipidemic treatments may also change the natural history of CVD in CKD patients and may represent important strategies in the management of CKD patients.

Indexed as

cardiovascular diseasechronic kidney diseaselipidslipoproteins

Identifiers

PMID33916487
PMCPMC8067409

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.