Evidence map›Paper›PMID 33917456›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Primary and Memory Response of Human Monocytes to Vaccines: Role of Nanoparticulate Antigens in Inducing Innate Memory.

Mayra M Ferrari Barbosa, Alex Issamu Kanno, Leonardo Paiva Farias, Mariusz Madej, Gergö Sipos, Silverio Sbrana, Luigina Romani, Diana Boraschi, Luciana C C Leite, Paola Italiani

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in immunology · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Mayra M Ferrari BarbosaLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP 05503-900, Brazil.ORCID 0000-0003-3602-1279
Alex Issamu KannoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP 05503-900, Brazil.
Leonardo Paiva FariasLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA 40296-710, Brazil.ORCID 0000-0002-4909-5333
Mariusz MadejIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, 80131 Napoli, Italy.
Gergö SiposIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, 80131 Napoli, Italy.
Silverio SbranaIstituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, 54100 Massa, Italy.ORCID 0000-0002-7811-4265
Luigina RomaniDipartimento di Medicina e Chirurgia, University of Perugia, 06132 Perugia, Italy.
Diana BoraschiIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, 80131 Napoli, Italy.ORCID 0000-0002-3953-4056
Luciana C C LeiteLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP 05503-900, Brazil.
Paola ItalianiIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, 80131 Napoli, Italy.
Instituto Butantan · BRStazione Zoologica Anton Dohrn · ITFundação Oswaldo Cruz · BRIstituto di Fisiologia Clinica · ITUniversity of Perugia · IT

Funding

Consiglio Nazionale delle Ricerche Joint Laboratories Initiative Italy-BrazilFundacao Butantan no numberFundação de Amparo à Pesquisa do Estado de São Paulo 2017/24632-6Horizon 2020 Framework Programme 671881Horizon 2020 Framework Programme 812661Ministero dell'Istruzione, dell'Università e della Ricerca InterOmics project MEMORATMinistero dell'Istruzione, dell'Università e della Ricerca PRIN project20173ZECCMSeventh Framework Programme 316383
6 · The paper itself

Abstract

Innate immune cells such as monocytes and macrophages are activated in response to microbial and other challenges and mount an inflammatory defensive response. Exposed cells develop the so-called innate memory, which allows them to react differently to a subsequent challenge, aiming at better protection. In this study, using human primary monocytes in vitro, we have assessed the memory-inducing capacity of two antigenic molecules of

Indexed as

innate immunityinnate memorymacrophagesmonocytesSchistosoma mansonivaccination

Identifiers

PMID33917456
PMCPMC8067467
OpenAlexW3145437244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.